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10.7717/peerj.10337

http://scihub22266oqcxt.onion/10.7717/peerj.10337
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33194455!7651477!33194455
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suck abstract from ncbi


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pmid33194455      PeerJ 2020 ; 8 (ä): e10337
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  • Deep learning prediction of likelihood of ICU admission and mortality in COVID-19 patients using clinical variables #MMPMID33194455
  • Li X; Ge P; Zhu J; Li H; Graham J; Singer A; Richman PS; Duong TQ
  • PeerJ 2020[]; 8 (ä): e10337 PMID33194455show ga
  • BACKGROUND: This study aimed to develop a deep-learning model and a risk-score system using clinical variables to predict intensive care unit (ICU) admission and in-hospital mortality in COVID-19 patients. METHODS: This retrospective study consisted of 5,766 persons-under-investigation for COVID-19 between 7 February 2020 and 4 May 2020. Demographics, chronic comorbidities, vital signs, symptoms and laboratory tests at admission were collected. A deep neural network model and a risk-score system were constructed to predict ICU admission and in-hospital mortality. Prediction performance used the receiver operating characteristic area under the curve (AUC). RESULTS: The top ICU predictors were procalcitonin, lactate dehydrogenase, C-reactive protein, ferritin and oxygen saturation. The top mortality predictors were age, lactate dehydrogenase, procalcitonin, cardiac troponin, C-reactive protein and oxygen saturation. Age and troponin were unique top predictors for mortality but not ICU admission. The deep-learning model predicted ICU admission and mortality with an AUC of 0.780 (95% CI [0.760-0.785]) and 0.844 (95% CI [0.839-0.848]), respectively. The corresponding risk scores yielded an AUC of 0.728 (95% CI [0.726-0.729]) and 0.848 (95% CI [0.847-0.849]), respectively. CONCLUSIONS: Deep learning and the resultant risk score have the potential to provide frontline physicians with quantitative tools to stratify patients more effectively in time-sensitive and resource-constrained circumstances.
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