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10.7717/peerj.9648 http://scihub22266oqcxt.onion/10.7717/peerj.9648 33194341!7394058!33194341     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PeerJ 2020 ; 8 (ä): e9648 Nephropedia Template TP {{tp|p=33194341|t=2020. Excessive G-U transversions in novel allele variants in SARS-CoV-2 genomes |pdf=|usr=}}{{33194341}} gab.com Text Excessive G-U transversions in novel allele variants in SARS-CoV-2 genomes JO: PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=33194341 #FOAvip BACKGROUND: SARS-CoV-2 is a novel coronavirus that causes COVID-19 infection, with a closest known relative found in bats. For this virus, hundreds of genomes have been sequenced. This data provides insights into SARS-CoV-2 adaptations, determinants of pathogenicity and mutation patterns. A comparison between patterns of mutations that occurred before and after SARS-CoV-2 jumped to human hosts may reveal important evolutionary consequences of zoonotic transmission. METHODS: We used publically available complete genomes of SARS-CoV-2 to calculate relative frequencies of single nucleotide variations. These frequencies were compared with relative substitutions frequencies between SARS-CoV-2 and related animal coronaviruses. A similar analysis was performed for human coronaviruses SARS-CoV and HKU1. RESULTS: We found a 9-fold excess of G-U transversions among SARS-CoV-2 mutations over relative substitution frequencies between SARS-CoV-2 and a close relative coronavirus from bats (RaTG13). This suggests that mutation patterns of SARS-CoV-2 have changed after transmission to humans. The excess of G-U transversions was much smaller in a similar analysis for SARS-CoV and non-existent for HKU1. Remarkably, we did not find a similar excess of complementary C-A mutations in SARS-CoV-2. We discuss possible explanations for these observations. Twit Text FOAVip Excessive G-U transversions in novel allele variants in SARS-CoV-2 genomes ????PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=33194341 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33194341 #FOAvip English Wikipedia <ref>{{Cite pmid|33194341}}</ref> Excessive G-U transversions in novel allele variants in SARS-CoV-2 genomes #MMPMID33194341 Panchin AY; Panchin YV PeerJ 2020[]; 8 (ä): e9648 PMID33194341show ga BACKGROUND: SARS-CoV-2 is a novel coronavirus that causes COVID-19 infection, with a closest known relative found in bats. For this virus, hundreds of genomes have been sequenced. This data provides insights into SARS-CoV-2 adaptations, determinants of pathogenicity and mutation patterns. A comparison between patterns of mutations that occurred before and after SARS-CoV-2 jumped to human hosts may reveal important evolutionary consequences of zoonotic transmission. METHODS: We used publically available complete genomes of SARS-CoV-2 to calculate relative frequencies of single nucleotide variations. These frequencies were compared with relative substitutions frequencies between SARS-CoV-2 and related animal coronaviruses. A similar analysis was performed for human coronaviruses SARS-CoV and HKU1. RESULTS: We found a 9-fold excess of G-U transversions among SARS-CoV-2 mutations over relative substitution frequencies between SARS-CoV-2 and a close relative coronavirus from bats (RaTG13). This suggests that mutation patterns of SARS-CoV-2 have changed after transmission to humans. The excess of G-U transversions was much smaller in a similar analysis for SARS-CoV and non-existent for HKU1. Remarkably, we did not find a similar excess of complementary C-A mutations in SARS-CoV-2. We discuss possible explanations for these observations. äExcessive G-U transversions in novel allele variants in SARS-CoV-2 gen(epmc).pdf DeepDyve Pubget Overpricing