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10.1155/2020/4587024 http://scihub22266oqcxt.onion/10.1155/2020/4587024 33194003!7641267!33194003     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oxid+Med+Cell+Longev 2020 ; 2020 (ä): 4587024 Nephropedia Template TP {{tp|p=33194003|t=2020. Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure |pdf=|usr=}}{{33194003}} gab.com Text Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=33194003 #FOAvip A large number of cannabinoids have been discovered that could play a role in mitigating cardiac affections. However, none of them has been as widely studied as cannabidiol (CBD), most likely because, individually, the others offer only partial effects or can activate potential harmful pathways. In this regard, CBD has proven to be of great value as a cardioprotective agent since it is a potent antioxidant and anti-inflammatory molecule. Thus, we conducted a review to condensate the currently available knowledge on CBD as a therapy for different experimental models of cardiomyopathies and heart failure to detect the molecular pathways involved in cardiac protection. CBD therapy can greatly limit the production of oxygen/nitrogen reactive species, thereby limiting cellular damage, protecting mitochondria, avoiding caspase activation, and regulating ionic homeostasis. Hence, it can affect myocardial contraction by restricting the activation of inflammatory pathways and cytokine secretion, lowering tissular infiltration by immune cells, and reducing the area of infarct and fibrosis formation. These effects are mediated by the activation or inhibition of different receptors and target molecules of the endocannabinoid system. In the final part of this review, we explore the current state of CBD in clinical trials as a treatment for cardiovascular diseases and provide evidence of its potential benefits in humans. Twit Text FOAVip Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=33194003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33194003 #FOAvip English Wikipedia <ref>{{Cite pmid|33194003}}</ref> Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart Failure #MMPMID33194003 Garza-Cervantes JA; Ramos-Gonzalez M; Lozano O; Jerjes-Sanchez C; Garcia-Rivas G Oxid Med Cell Longev 2020[]; 2020 (ä): 4587024 PMID33194003show ga A large number of cannabinoids have been discovered that could play a role in mitigating cardiac affections. However, none of them has been as widely studied as cannabidiol (CBD), most likely because, individually, the others offer only partial effects or can activate potential harmful pathways. In this regard, CBD has proven to be of great value as a cardioprotective agent since it is a potent antioxidant and anti-inflammatory molecule. Thus, we conducted a review to condensate the currently available knowledge on CBD as a therapy for different experimental models of cardiomyopathies and heart failure to detect the molecular pathways involved in cardiac protection. CBD therapy can greatly limit the production of oxygen/nitrogen reactive species, thereby limiting cellular damage, protecting mitochondria, avoiding caspase activation, and regulating ionic homeostasis. Hence, it can affect myocardial contraction by restricting the activation of inflammatory pathways and cytokine secretion, lowering tissular infiltration by immune cells, and reducing the area of infarct and fibrosis formation. These effects are mediated by the activation or inhibition of different receptors and target molecules of the endocannabinoid system. In the final part of this review, we explore the current state of CBD in clinical trials as a treatment for cardiovascular diseases and provide evidence of its potential benefits in humans. |*Cardiomyopathies/drug therapy/metabolism/physiopathology[MESH] |*Heart Failure/drug therapy/metabolism/physiopathology[MESH] |Anti-Inflammatory Agents/*therapeutic use[MESH] |Cannabidiol/*therapeutic use[MESH] |Cardiotonic Agents/*therapeutic use[MESH] |Humans[MESH] |Myocardial Contraction/drug effects[MESH]Therapeutic Applications of Cannabinoids in Cardiomyopathy and Heart F(epmc).pdf DeepDyve Pubget Overpricing