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10.3389/fimmu.2020.562264 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.562264 33193331!7652766!33193331     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 562264 Nephropedia Template TP {{tp|p=33193331|t=2020. A 21st Century Evil: Immunopathology and New Therapies of COVID-19 |pdf=|usr=}}{{33193331}} gab.com Text A 21st Century Evil: Immunopathology and New Therapies of COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33193331 #FOAvip Coronavirus Disease 2019 (COVID-19) has been classified as a global threat, affecting millions of people and killing thousands. It is caused by the SARS-CoV-2 virus, which emerged at the end of 2019 in Wuhan, China, quickly spreading worldwide. COVID-19 is a disease with symptoms that range from fever and breathing difficulty to acute respiratory distress and death, critically affecting older patients and people with previous comorbidities. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor and mainly spreads through the respiratory tract, which it then uses to reach several organs. The immune system of infected patients has been demonstrated to suffer important alterations, such as lymphopenia, exhausted lymphocytes, excessive amounts of inflammatory monocytes and macrophages, especially in the lungs, and cytokine storms, which may contribute to its severity and difficulty of establishing an effective treatment. Even though no specific treatment is currently available, several studies have been investigating potential therapeutic strategies, including the use of previously approved drugs and immunotherapy. In this context, this review addresses the interaction between SARS-CoV-2 and the patient's host immune system during infection, in addition to discussing the main immunopathological mechanisms involved in the development of the disease and potential new therapeutic approaches. Twit Text FOAVip A 21st Century Evil: Immunopathology and New Therapies of COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33193331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33193331 #FOAvip English Wikipedia <ref>{{Cite pmid|33193331}}</ref> A 21st Century Evil: Immunopathology and New Therapies of COVID-19 #MMPMID33193331 Silva TF; Tomiotto-Pellissier F; Sanfelice RA; Goncalves MD; da Silva Bortoleti BT; Detoni MB; Rodrigues ACJ; Carloto ACM; Concato VM; Siqueira EDS; Costa IN; Pavanelli WR; Conchon-Costa I; Miranda-Sapla MM Front Immunol 2020[]; 11 (ä): 562264 PMID33193331show ga Coronavirus Disease 2019 (COVID-19) has been classified as a global threat, affecting millions of people and killing thousands. It is caused by the SARS-CoV-2 virus, which emerged at the end of 2019 in Wuhan, China, quickly spreading worldwide. COVID-19 is a disease with symptoms that range from fever and breathing difficulty to acute respiratory distress and death, critically affecting older patients and people with previous comorbidities. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor and mainly spreads through the respiratory tract, which it then uses to reach several organs. The immune system of infected patients has been demonstrated to suffer important alterations, such as lymphopenia, exhausted lymphocytes, excessive amounts of inflammatory monocytes and macrophages, especially in the lungs, and cytokine storms, which may contribute to its severity and difficulty of establishing an effective treatment. Even though no specific treatment is currently available, several studies have been investigating potential therapeutic strategies, including the use of previously approved drugs and immunotherapy. In this context, this review addresses the interaction between SARS-CoV-2 and the patient's host immune system during infection, in addition to discussing the main immunopathological mechanisms involved in the development of the disease and potential new therapeutic approaches. |Angiotensin-Converting Enzyme 2/genetics/immunology[MESH] |COVID-19/genetics/*immunology/therapy/virology[MESH] |Humans[MESH] |Immunotherapy[MESH] |Macrophages[MESH] |Pandemics[MESH]A 21st Century Evil: Immunopathology and New Therapies of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing