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10.3389/fphys.2020.585907 http://scihub22266oqcxt.onion/10.3389/fphys.2020.585907 33192599!7606576!33192599     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2020 ; 11 (ä): 585907 Nephropedia Template TP {{tp|p=33192599|t=2020. Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters |pdf=|usr=}}{{33192599}} gab.com Text Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33192599 #FOAvip The role of Cl(-) as an intracellular signaling ion has been increasingly recognized in recent years. One of the currently best described roles of Cl(-) in signaling is the modulation of the With-No-Lysine (K) (WNK) - STE20-Proline Alanine rich Kinase (SPAK)/Oxidative Stress Responsive Kinase 1 (OSR1) - Cation-Coupled Cl(-) Cotransporters (CCCs) cascade. Binding of a Cl(-) anion to the active site of WNK kinases directly modulates their activity, promoting their inhibition. WNK activation due to Cl(-) release from the binding site leads to phosphorylation and activation of SPAK/OSR1, which in turn phosphorylate the CCCs. Phosphorylation by WNKs-SPAK/OSR1 of the Na(+)-driven CCCs (mediating ions influx) promote their activation, whereas that of the K(+)-driven CCCs (mediating ions efflux) promote their inhibition. This results in net Cl(-) influx and feedback inhibition of WNK kinases. A wide variety of alterations to this pathway have been recognized as the cause of several human diseases, with manifestations in different systems. The understanding of WNK kinases as Cl(-) sensitive proteins has allowed us to better understand the mechanistic details of regulatory processes involved in diverse physiological phenomena that are reviewed here. These include cell volume regulation, potassium sensing and intracellular signaling in the renal distal convoluted tubule, and regulation of the neuronal response to the neurotransmitter GABA. Twit Text FOAVip Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33192599 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33192599 #FOAvip English Wikipedia <ref>{{Cite pmid|33192599}}</ref> Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters #MMPMID33192599 Murillo-de-Ozores AR; Chavez-Canales M; de Los Heros P; Gamba G; Castaneda-Bueno M Front Physiol 2020[]; 11 (ä): 585907 PMID33192599show ga The role of Cl(-) as an intracellular signaling ion has been increasingly recognized in recent years. One of the currently best described roles of Cl(-) in signaling is the modulation of the With-No-Lysine (K) (WNK) - STE20-Proline Alanine rich Kinase (SPAK)/Oxidative Stress Responsive Kinase 1 (OSR1) - Cation-Coupled Cl(-) Cotransporters (CCCs) cascade. Binding of a Cl(-) anion to the active site of WNK kinases directly modulates their activity, promoting their inhibition. WNK activation due to Cl(-) release from the binding site leads to phosphorylation and activation of SPAK/OSR1, which in turn phosphorylate the CCCs. Phosphorylation by WNKs-SPAK/OSR1 of the Na(+)-driven CCCs (mediating ions influx) promote their activation, whereas that of the K(+)-driven CCCs (mediating ions efflux) promote their inhibition. This results in net Cl(-) influx and feedback inhibition of WNK kinases. A wide variety of alterations to this pathway have been recognized as the cause of several human diseases, with manifestations in different systems. The understanding of WNK kinases as Cl(-) sensitive proteins has allowed us to better understand the mechanistic details of regulatory processes involved in diverse physiological phenomena that are reviewed here. These include cell volume regulation, potassium sensing and intracellular signaling in the renal distal convoluted tubule, and regulation of the neuronal response to the neurotransmitter GABA. äPhysiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/O(epmc).pdf DeepDyve Pubget Overpricing