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10.1016/j.clim.2020.108630 http://scihub22266oqcxt.onion/10.1016/j.clim.2020.108630 33189887!7661928!33189887     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2021 ; 222 (ä): 108630 Nephropedia Template TP {{tp|p=33189887|t=2021. Major reduction of NKT cells in patients with severe COVID-19 pneumonia |pdf=|usr=}}{{33189887}} gab.com Text Major reduction of NKT cells in patients with severe COVID-19 pneumonia JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33189887 #FOAvip BACKGROUND: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. METHODS: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. RESULTS: Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. CONCLUSIONS: The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset. Twit Text FOAVip Major reduction of NKT cells in patients with severe COVID-19 pneumonia ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33189887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33189887 #FOAvip English Wikipedia <ref>{{Cite pmid|33189887}}</ref> Major reduction of NKT cells in patients with severe COVID-19 pneumonia #MMPMID33189887 Zingaropoli MA; Perri V; Pasculli P; Cogliati Dezza F; Nijhawan P; Savelloni G; La Torre G; D'Agostino C; Mengoni F; Lichtner M; Ciardi MR; Mastroianni CM Clin Immunol 2021[Jan]; 222 (ä): 108630 PMID33189887show ga BACKGROUND: NK cells seem to be mainly involved in COVID-19 pneumonia. Little is known about NKT cells which represent a bridge between innate and adaptive immunity. METHODS: We characterized peripheral blood T, NK and NKT cells in 45 patients with COVID-19 pneumonia (COVID-19 subjects) and 19 healthy donors (HDs). According to the severity of the disease, we stratified COVID-19 subjects into severe and non-severe groups. RESULTS: Compared to HDs, COVID-19 subjects showed higher percentages of NK CD57+ and CD56dim NK cells and lower percentages of NKT and CD56bright cells. In the severe group we found a significantly lower percentage of NKT cells. In a multiple logistic regression analysis, NKT cell was independently associated with the severity of the disease. CONCLUSIONS: The low percentage of NKT cells in peripheral blood of COVID-19 subjects and the independent association with the severity of the disease suggests a potential role of this subset. |*SARS-CoV-2[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antigens, CD/genetics/metabolism[MESH] |COVID-19/*pathology[MESH] |Female[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Major reduction of NKT cells in patients with severe COVID-19 pneumoni(epmc).pdf DeepDyve Pubget Overpricing