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10.1016/j.pharmthera.2020.107745 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2020.107745 33188794!7657264!33188794     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Ther 2021 ; 221 (ä): 107745 Nephropedia Template TP {{tp|p=33188794|t=2021. Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19 |pdf=|usr=}}{{33188794}} gab.com Text Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19 JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33188794 #FOAvip While COVID-19, the disease driven by SARS-CoV-2 has ignited interest in the host immune response to this infection, it has also highlighted the lack of treatment options for the damaging inflammatory responses driven by pathogens that precipitate the acute respiratory distress syndrome (ARDS). With the global prevalence of SARS-CoV-2 and the likelihood of a second winter spike alongside seasonal flu, the need for effective and targeted anti-inflammatory agents is even more pressing. Here we discuss the aetiology of COVID-19 and the common signalling pathways driven by SARS-CoV-2, namely p38 MAP kinase. We highlight that p38 MAP kinase becomes elevated with increasing age, thereby driving many of the inflammatory pathways that precipitate death in old people with the added drawback of impairing vaccine efficacy in this susceptible age group. Finally, we review drugs available to inhibit p38 MAP kinase, their risks-versus-benefits as well as suggested dosing regimen to combat over-exuberant innate immune responses and potentially reverse vaccine inefficacy in older patients. Twit Text FOAVip Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19 ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33188794 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33188794 #FOAvip English Wikipedia <ref>{{Cite pmid|33188794}}</ref> Treating exuberant, non-resolving inflammation in the lung; Implications for acute respiratory distress syndrome and COVID-19 #MMPMID33188794 Gilroy DW; De Maeyer RPH; Tepper M; O'Brien A; Uddin M; Chen J; Goldstein DR; Akbar AN Pharmacol Ther 2021[May]; 221 (ä): 107745 PMID33188794show ga While COVID-19, the disease driven by SARS-CoV-2 has ignited interest in the host immune response to this infection, it has also highlighted the lack of treatment options for the damaging inflammatory responses driven by pathogens that precipitate the acute respiratory distress syndrome (ARDS). With the global prevalence of SARS-CoV-2 and the likelihood of a second winter spike alongside seasonal flu, the need for effective and targeted anti-inflammatory agents is even more pressing. Here we discuss the aetiology of COVID-19 and the common signalling pathways driven by SARS-CoV-2, namely p38 MAP kinase. We highlight that p38 MAP kinase becomes elevated with increasing age, thereby driving many of the inflammatory pathways that precipitate death in old people with the added drawback of impairing vaccine efficacy in this susceptible age group. Finally, we review drugs available to inhibit p38 MAP kinase, their risks-versus-benefits as well as suggested dosing regimen to combat over-exuberant innate immune responses and potentially reverse vaccine inefficacy in older patients. |*COVID-19 Drug Treatment[MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use[MESH] |COVID-19/epidemiology/immunology[MESH] |Clinical Trials as Topic/methods[MESH] |Humans[MESH] |Immunity, Innate/drug effects/immunology[MESH] |MAP Kinase Signaling System/*drug effects/physiology[MESH] |Pneumonia/*drug therapy/epidemiology/immunology[MESH] |Protein Kinase Inhibitors/pharmacology/*therapeutic use[MESH]Treating exuberant, non-resolving inflammation in the lung; Implicatio(epmc).pdf DeepDyve Pubget Overpricing