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10.1016/j.cell.2020.10.019 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.10.019 33188777!7664544!33188777     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33188777&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell 2020 ; 183 (7): 1930-1945.e23 Nephropedia Template TP {{tp|p=33188777|t=2020. Translation and Replication Dynamics of Single RNA Viruses |pdf=|usr=}}{{33188777}} gab.com Text Translation and Replication Dynamics of Single RNA Viruses JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33188777 #FOAvip RNA viruses are among the most prevalent pathogens and are a major burden on society. Although RNA viruses have been studied extensively, little is known about the processes that occur during the first several hours of infection because of a lack of sensitive assays. Here we develop a single-molecule imaging assay, virus infection real-time imaging (VIRIM), to study translation and replication of individual RNA viruses in live cells. VIRIM uncovered a striking heterogeneity in replication dynamics between cells and revealed extensive coordination between translation and replication of single viral RNAs. Furthermore, using VIRIM, we identify the replication step of the incoming viral RNA as a major bottleneck of successful infection and identify host genes that are responsible for inhibition of early virus replication. Single-molecule imaging of virus infection is a powerful tool to study virus replication and virus-host interactions that may be broadly applicable to RNA viruses. Twit Text FOAVip Translation and Replication Dynamics of Single RNA Viruses ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33188777 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33188777 #FOAvip English Wikipedia <ref>{{Cite pmid|33188777}}</ref> Translation and Replication Dynamics of Single RNA Viruses #MMPMID33188777 Boersma S; Rabouw HH; Bruurs LJM; Pavlovic T; van Vliet ALW; Beumer J; Clevers H; van Kuppeveld FJM; Tanenbaum ME Cell 2020[Dec]; 183 (7): 1930-1945.e23 PMID33188777show ga RNA viruses are among the most prevalent pathogens and are a major burden on society. Although RNA viruses have been studied extensively, little is known about the processes that occur during the first several hours of infection because of a lack of sensitive assays. Here we develop a single-molecule imaging assay, virus infection real-time imaging (VIRIM), to study translation and replication of individual RNA viruses in live cells. VIRIM uncovered a striking heterogeneity in replication dynamics between cells and revealed extensive coordination between translation and replication of single viral RNAs. Furthermore, using VIRIM, we identify the replication step of the incoming viral RNA as a major bottleneck of successful infection and identify host genes that are responsible for inhibition of early virus replication. Single-molecule imaging of virus infection is a powerful tool to study virus replication and virus-host interactions that may be broadly applicable to RNA viruses. |*Protein Biosynthesis[MESH] |Cell Line, Tumor[MESH] |Cell Survival[MESH] |HEK293 Cells[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |RNA Transport[MESH] |RNA Viruses/*physiology[MESH] |RNA, Viral/genetics[MESH] |Reproducibility of Results[MESH] |Single Molecule Imaging[MESH] |Time Factors[MESH]Translation and Replication Dynamics of Single RNA Viruses (epmc).pdf DeepDyve Pubget Overpricing