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10.1093/jpids/piaa148

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33188394!7717321!33188394
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suck abstract from ncbi


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pmid33188394      J+Pediatric+Infect+Dis+Soc 2021 ; 10 (4): 543-546
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  • SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down Syndrome #MMPMID33188394
  • Kim-Hellmuth S; Hermann M; Eilenberger J; Ley-Zaporozhan J; Fischer M; Hauck F; Klein C; Haas N; Kappler M; Huebner J; Jakob A; von Both U
  • J Pediatric Infect Dis Soc 2021[Apr]; 10 (4): 543-546 PMID33188394show ga
  • Down syndrome (DS) predisposes to severe immunologic reaction secondary to infectious triggers. Here, we report a pediatric DS patient with coronavirus disease 2019 (COVID-19) who developed a hyperinflammatory syndrome, severe acute respiratory distress syndrome, and secondary hemophagocytic lymphohistiocytosis requiring pediatric intensive care unit admission and treatment with steroids, intravenous immunoglobulin, and remdesivir. Investigations into genetic susceptibilities for COVID-19 and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated complications warrant systematic clinical and scientific studies. We report a pediatric Down syndrome patient with coronavirus disease 2019 (COVID-19) who developed secondary hemophagocytic lymphohistiocytosis requiring treatment with steroids, intravenous immunoglobulin, and remdesivir. Investigations into genetic susceptibilities for COVID-19-associated complications warrant systematic clinical and scientific studies.
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19/*complications/diagnosis/virology[MESH]
  • |Child, Preschool[MESH]
  • |Critical Care[MESH]
  • |Down Syndrome/*complications[MESH]
  • |Genetic Predisposition to Disease[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/therapeutic use[MESH]
  • |Lymphohistiocytosis, Hemophagocytic/diagnosis/drug therapy/*virology[MESH]
  • |Male[MESH]
  • |Prednisolone/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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