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10.1038/s41598-020-74988-9

http://scihub22266oqcxt.onion/10.1038/s41598-020-74988-9
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33188232!7666204!33188232
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suck abstract from ncbi

pmid33188232      Sci+Rep 2020 ; 10 (1): 19765
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  • Clinical presentations, laboratory and radiological findings, and treatments for 11,028 COVID-19 patients: a systematic review and meta-analysis #MMPMID33188232
  • Wong CKH; Wong JYH; Tang EHM; Au CH; Wai AKC
  • Sci Rep 2020[Nov]; 10 (1): 19765 PMID33188232show ga
  • This systematic review and meta-analysis investigated the comorbidities, symptoms, clinical characteristics and treatment of COVID-19 patients. Epidemiological studies published in 2020 (from January-March) on the clinical presentation, laboratory findings and treatments of COVID-19 patients were identified from PubMed/MEDLINE and Embase databases. Studies published in English by 27th March, 2020 with original data were included. Primary outcomes included comorbidities of COVID-19 patients, their symptoms presented on hospital admission, laboratory results, radiological outcomes, and pharmacological and in-patient treatments. 76 studies were included in this meta-analysis, accounting for a total of 11,028 COVID-19 patients in multiple countries. A random-effects model was used to aggregate estimates across eligible studies and produce meta-analytic estimates. The most common comorbidities were hypertension (18.1%, 95% CI 15.4-20.8%). The most frequently identified symptoms were fever (72.4%, 95% CI 67.2-77.7%) and cough (55.5%, 95% CI 50.7-60.3%). For pharmacological treatment, 63.9% (95% CI 52.5-75.3%), 62.4% (95% CI 47.9-76.8%) and 29.7% (95% CI 21.8-37.6%) of patients were given antibiotics, antiviral, and corticosteroid, respectively. Notably, 62.6% (95% CI 39.9-85.4%) and 20.2% (95% CI 14.6-25.9%) of in-patients received oxygen therapy and non-invasive mechanical ventilation, respectively. This meta-analysis informed healthcare providers about the timely status of characteristics and treatments of COVID-19 patients across different countries.PROSPERO Registration Number: CRD42020176589.
  • |Adrenal Cortex Hormones/administration & dosage/therapeutic use[MESH]
  • |Anti-Bacterial Agents/administration & dosage/therapeutic use[MESH]
  • |Antiviral Agents/administration & dosage/therapeutic use[MESH]
  • |COVID-19 Testing/statistics & numerical data[MESH]
  • |COVID-19/diagnosis/*epidemiology/therapy[MESH]
  • |Comorbidity[MESH]
  • |Drug Utilization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Hypertension/epidemiology[MESH]
  • |Oxygen Inhalation Therapy/statistics & numerical data[MESH]


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