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10.1126/sciadv.abe3024

http://scihub22266oqcxt.onion/10.1126/sciadv.abe3024
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33187979!7725462!33187979
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suck abstract from ncbi


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pmid33187979      Sci+Adv 2020 ; 6 (50): ä
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  • Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm #MMPMID33187979
  • Mudd PA; Crawford JC; Turner JS; Souquette A; Reynolds D; Bender D; Bosanquet JP; Anand NJ; Striker DA; Martin RS; Boon ACM; House SL; Remy KE; Hotchkiss RS; Presti RM; O'Halloran JA; Powderly WG; Thomas PG; Ellebedy AH
  • Sci Adv 2020[Dec]; 6 (50): ä PMID33187979show ga
  • We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface human leukocyte antigen (HLA)-class II expression on selected monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes predicted severe COVID-19 disease. In contrast to prevailing assumptions, very few (7 of 168) patients with COVID-19 exhibited cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors including age and sample time point, patients with COVID-19 exhibited lower cytokine levels than patients with influenza. Up-regulation of IL-6, G-CSF, IL-1RA, and MCP1 predicted death in patients with COVID-19 but were not statistically higher than patients with influenza. Single-cell transcriptional profiling revealed profound suppression of interferon signaling among patients with COVID-19. When considered across the spectrum of peripheral immune profiles, patients with COVID-19 are less inflamed than patients with influenza.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/diagnosis/genetics/*immunology[MESH]
  • |Cells, Cultured[MESH]
  • |Cytokine Release Syndrome/genetics/*immunology/metabolism[MESH]
  • |Cytokines/genetics/*immunology/metabolism[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Gene Expression Profiling/methods[MESH]
  • |Humans[MESH]
  • |Inflammation/genetics/*immunology[MESH]
  • |Influenza, Human/diagnosis/genetics/*immunology[MESH]
  • |Leukocytes, Mononuclear/immunology/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]


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