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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Adv 2020 ; 6 (50): ä Nephropedia Template TP
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Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm #MMPMID33187979
Mudd PA; Crawford JC; Turner JS; Souquette A; Reynolds D; Bender D; Bosanquet JP; Anand NJ; Striker DA; Martin RS; Boon ACM; House SL; Remy KE; Hotchkiss RS; Presti RM; O'Halloran JA; Powderly WG; Thomas PG; Ellebedy AH
Sci Adv 2020[Dec]; 6 (50): ä PMID33187979show ga
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, patients with COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface human leukocyte antigen (HLA)-class II expression on selected monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes predicted severe COVID-19 disease. In contrast to prevailing assumptions, very few (7 of 168) patients with COVID-19 exhibited cytokine profiles indicative of cytokine storm syndrome. After controlling for multiple factors including age and sample time point, patients with COVID-19 exhibited lower cytokine levels than patients with influenza. Up-regulation of IL-6, G-CSF, IL-1RA, and MCP1 predicted death in patients with COVID-19 but were not statistically higher than patients with influenza. Single-cell transcriptional profiling revealed profound suppression of interferon signaling among patients with COVID-19. When considered across the spectrum of peripheral immune profiles, patients with COVID-19 are less inflamed than patients with influenza.