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suck abstract from ncbi


10.1016/j.blre.2020.100775

http://scihub22266oqcxt.onion/10.1016/j.blre.2020.100775
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33187811!7833659!33187811
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suck abstract from ncbi

pmid33187811      Blood+Rev 2021 ; 47 (?): 100775
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  • When hematologic malignancies meet COVID-19 in the United States: Infections, death and disparities #MMPMID33187811
  • Wang Q; Berger NA; Xu R
  • Blood Rev 2021[May]; 47 (?): 100775 PMID33187811show ga
  • Scientific data is limited on the risks, adverse outcomes and racial disparities for COVID-19 illness in individuals with hematologic malignancies in the United States. To fill this void, we screened and analyzed a nation-wide database of patient electronic health records (EHRs) of 73 million patients in the US (up to September 1st) for COVID-19 and eight major types of hematologic malignancies. Patients with hematologic malignancies had increased odds of COVID-19 infection compared with patients without hematologic malignancies for both all-time diagnosis (malignancy diagnosed in the past year or prior) (adjusted Odds ratio or AOR: 2.27 [2.17-2.36], p < 0.001) and recent diagnosis (malignancy diagnosed in the past year) (AOR:11.91 [11.31-12.53], p < 0.001), with strongest effect for recently diagnosed acute lymphoid leukemia (AOR: 31.03 [25.87-37.27], p < 0.001), essential thrombocythemia (AOR: 20.65 [19.10-22.32], p < 0.001), acute myeloid leukemia (AOR: 18.94 [15.79-22.73], p < 0.001), multiple myeloma (AOR: 14.21 [12.72-15.89], p < 0.001). Among patients with hematologic malignancies, African Americans had higher odds of COVID-19 infection than Caucasians with largest racial disparity for multiple myeloma (AOR: 4.23 [3.21-5.56], p < 0.001). Patients with recently diagnosed hematologic malignancies had worse outcomes (hospitalization: 51.9%, death: 14.8%) than COVID-19 patients without hematologic malignancies (hospitalization: 23.5%, death: 5.1%) (p < 0.001) and hematologic malignancy patients without COVID-19 (hospitalization: 15.0%, death: 4.1%) (p < 0.001).
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Female[MESH]
  • |Health Status Disparities[MESH]
  • |Hematologic Neoplasms/*complications/epidemiology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Leukemia, Myeloid, Acute/complications/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multiple Myeloma/complications/epidemiology[MESH]
  • |Odds Ratio[MESH]
  • |Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/epidemiology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |United States/epidemiology[MESH]


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