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10.1016/j.clnu.2020.10.055 http://scihub22266oqcxt.onion/10.1016/j.clnu.2020.10.055 33187772!7605851!33187772     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33187772&cmd=llinks): Failed to open stream: HTTP request failed! 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Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital |pdf=|usr=}}{{33187772}} gab.com Text Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital JO: Clin Nutr http://www.kidney.de/pget.php?&tw=1&pmid=33187772 #FOAvip BACKGROUND & AIMS: Great interest has been raised by the possible protective role of vitamin D in coronavirus disease 2019 (COVID-19), but objective data on 25(OH)vitamin D deficiency in hospitalized COVID-19 patients are not conclusive. The aim of this study was to determine the prevalence of 25(OH)vitamin D deficiency in COVID-19 patients admitted to an Italian referral hospital and explore its association with clinical outcomes and the markers of disease severity. METHODS: In this single-center cohort study, 129 consecutive adult COVID-19 patients hospitalized in an Italian referral center were enrolled from March to April 2020. 25(OH)Vitamin D serum levels were assessed 48 h since hospital admission and categorized into: normal (>/=30 ng/mL), insufficient (<30 - >/=20 ng/mL), moderately deficient (<20 - >/=10 ng/mL), severely deficient (<10 ng/mL). RESULTS: The prevalence of 25(OH)vitamin D insufficiency, moderate deficiency and severe deficiency was 13.2%, 22.5% and 54.3%, respectively. 25(OH)Vitamin D deficiency (<20 ng/mL) was not associated with COVID-19 clinical features and outcomes. Unexpectedly, after adjusting for major confounders, a significant positive association between increasing 25(OH)vitamin D levels and in-hospital mortality (on a continuous logarithmic scale, odds ratio = 1.73 [95% CI, 1.11 to 2.69]; P = .016) was observed. CONCLUSIONS: Very low 25(OH)vitamin D levels were highly prevalent and suggestive of deficiency among our hospitalized severe COVID-19 patients, but low 25(OH)vitamin D levels were not associated with outcome variables. Whether 25(OH)vitamin D adequacy may influence clinical outcomes in COVID-19 and the unexpected correlation between higher 25(OH)vitamin D levels and mortality require further investigations by large intervention trials. Twit Text FOAVip Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital ????Clin Nutr http://www.kidney.de/pget.php?&tw=1&pmid=33187772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33187772 #FOAvip English Wikipedia <ref>{{Cite pmid|33187772}}</ref> Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital #MMPMID33187772 Cereda E; Bogliolo L; Klersy C; Lobascio F; Masi S; Crotti S; De Stefano L; Bruno R; Corsico AG; Di Sabatino A; Perlini S; Montecucco C; Caccialanza R Clin Nutr 2021[Apr]; 40 (4): 2469-2472 PMID33187772show ga BACKGROUND & AIMS: Great interest has been raised by the possible protective role of vitamin D in coronavirus disease 2019 (COVID-19), but objective data on 25(OH)vitamin D deficiency in hospitalized COVID-19 patients are not conclusive. The aim of this study was to determine the prevalence of 25(OH)vitamin D deficiency in COVID-19 patients admitted to an Italian referral hospital and explore its association with clinical outcomes and the markers of disease severity. METHODS: In this single-center cohort study, 129 consecutive adult COVID-19 patients hospitalized in an Italian referral center were enrolled from March to April 2020. 25(OH)Vitamin D serum levels were assessed 48 h since hospital admission and categorized into: normal (>/=30 ng/mL), insufficient (<30 - >/=20 ng/mL), moderately deficient (<20 - >/=10 ng/mL), severely deficient (<10 ng/mL). RESULTS: The prevalence of 25(OH)vitamin D insufficiency, moderate deficiency and severe deficiency was 13.2%, 22.5% and 54.3%, respectively. 25(OH)Vitamin D deficiency (<20 ng/mL) was not associated with COVID-19 clinical features and outcomes. Unexpectedly, after adjusting for major confounders, a significant positive association between increasing 25(OH)vitamin D levels and in-hospital mortality (on a continuous logarithmic scale, odds ratio = 1.73 [95% CI, 1.11 to 2.69]; P = .016) was observed. CONCLUSIONS: Very low 25(OH)vitamin D levels were highly prevalent and suggestive of deficiency among our hospitalized severe COVID-19 patients, but low 25(OH)vitamin D levels were not associated with outcome variables. Whether 25(OH)vitamin D adequacy may influence clinical outcomes in COVID-19 and the unexpected correlation between higher 25(OH)vitamin D levels and mortality require further investigations by large intervention trials. |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |COVID-19/*pathology[MESH] |Cohort Studies[MESH] |Female[MESH] |Hospital Mortality[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Tertiary Care Centers[MESH] |Vitamin D Deficiency/*blood[MESH]Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary (epmc).pdf DeepDyve Pubget Overpricing