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10.3390/cells9112458 http://scihub22266oqcxt.onion/10.3390/cells9112458 33187255!7698018!33187255     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2020 ; 9 (11): ä Nephropedia Template TP {{tp|p=33187255|t=2020. Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence |pdf=|usr=}}{{33187255}} gab.com Text Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=33187255 #FOAvip Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary causes of fat accumulation. NAFLD encompasses a wide spectrum of liver damage, extending from simple steatosis or non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH)-the latter is characterized by inflammation and hepatocyte ballooning degeneration, in addition to the steatosis, with or without fibrosis. NAFLD is now the most common cause of chronic liver disease in Western countries and affects around one quarter of the general population. It is a multisystem disorder, which is associated with an increased risk of type 2 diabetes mellitus as well as liver- and cardiovascular-related mortality. Although earlier studies had suggested that NAFL is benign (i.e., non-progressive), cumulative evidence challenges this dogma, and recent data suggest that nearly 25% of those with NAFL may develop fibrosis. Importantly, NAFLD patients are more susceptible to the toxic effects of alcohol, drugs, and other insults to the liver. This is likely due to the functional impairment of steatotic hepatocytes, which is virtually undetectable by current clinical tests. This review provides an overview of the current evidence on the clinical significance of NAFL and discusses the molecular basis for NAFL development and progression. Twit Text FOAVip Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=33187255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33187255 #FOAvip English Wikipedia <ref>{{Cite pmid|33187255}}</ref> Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence #MMPMID33187255 Mazzolini G; Sowa JP; Atorrasagasti C; Kucukoglu O; Syn WK; Canbay A Cells 2020[Nov]; 9 (11): ä PMID33187255show ga Non-alcoholic fatty liver disease (NAFLD) is defined clinicopathologically by the accumulation of lipids in >5% of hepatocytes and the exclusion of secondary causes of fat accumulation. NAFLD encompasses a wide spectrum of liver damage, extending from simple steatosis or non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH)-the latter is characterized by inflammation and hepatocyte ballooning degeneration, in addition to the steatosis, with or without fibrosis. NAFLD is now the most common cause of chronic liver disease in Western countries and affects around one quarter of the general population. It is a multisystem disorder, which is associated with an increased risk of type 2 diabetes mellitus as well as liver- and cardiovascular-related mortality. Although earlier studies had suggested that NAFL is benign (i.e., non-progressive), cumulative evidence challenges this dogma, and recent data suggest that nearly 25% of those with NAFL may develop fibrosis. Importantly, NAFLD patients are more susceptible to the toxic effects of alcohol, drugs, and other insults to the liver. This is likely due to the functional impairment of steatotic hepatocytes, which is virtually undetectable by current clinical tests. This review provides an overview of the current evidence on the clinical significance of NAFL and discusses the molecular basis for NAFL development and progression. |Animals[MESH] |COVID-19/complications[MESH] |Disease Progression[MESH] |Endoplasmic Reticulum Stress[MESH] |Fatty Liver/*genetics/*pathology/physiopathology[MESH] |Humans[MESH] |Liver/injuries/pathology[MESH]Significance of Simple Steatosis: An Update on the Clinical and Molecu(epmc).pdf DeepDyve Pubget Overpricing