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10.1016/j.ymthe.2020.10.001 http://scihub22266oqcxt.onion/10.1016/j.ymthe.2020.10.001 33186542!7543694!33186542     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2020 ; 28 (12): 2691-2702 Nephropedia Template TP {{tp|p=33186542|t=2020. COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a(+) |pdf=|usr=}}{{33186542}} gab.com Text COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a(+) JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33186542 #FOAvip Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is an unsolved challenge. The involvement of T cell immunity in this exacerbation remains unclear. To identify predictive markers of COVID-19 progress and outcome, we analyzed peripheral blood of 10 COVID-19-associated ARDS patients and 35 mild/moderate COVID-19 patients, not requiring intensive care. Using multi-parametric flow cytometry, we compared quantitative, phenotypic, and functional characteristics of circulating bulk immune cells, as well as SARS-CoV-2 S-protein-reactive T cells between the two groups. ARDS patients demonstrated significantly higher S-protein-reactive CD4(+) and CD8(+) T cells compared to non-ARDS patients. Of interest, comparison of circulating bulk T cells in ARDS patients to non-ARDS patients demonstrated decreased frequencies of CD4(+) and CD8(+) T cell subsets, with activated memory/effector T cells expressing tissue migration molecule CD11a(+)(+). Importantly, survival from ARDS (4/10) was accompanied by a recovery of the CD11a(+)(+) T cell subsets in peripheral blood. Conclusively, data on S-protein-reactive polyfunctional T cells indicate the ability of ARDS patients to generate antiviral protection. Furthermore, decreased frequencies of activated memory/effector T cells expressing tissue migratory molecule CD11a(+)(+) observed in circulation of ARDS patients might suggest their involvement in ARDS development and propose the CD11a-based immune signature as a possible prognostic marker. Twit Text FOAVip COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a(+) ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=33186542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33186542 #FOAvip English Wikipedia <ref>{{Cite pmid|33186542}}</ref> COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a(+) #MMPMID33186542 Anft M; Paniskaki K; Blazquez-Navarro A; Doevelaar A; Seibert FS; Holzer B; Skrzypczyk S; Kohut E; Kurek J; Zapka J; Wehler P; Kaliszczyk S; Bajda S; Thieme CJ; Roch T; Konik MJ; Berger MM; Brenner T; Kolsch U; Meister TL; Pfaender S; Steinmann E; Tempfer C; Watzl C; Dolff S; Dittmer U; Abou-El-Enein M; Westhoff TH; Witzke O; Stervbo U; Babel N Mol Ther 2020[Dec]; 28 (12): 2691-2702 PMID33186542show ga Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is an unsolved challenge. The involvement of T cell immunity in this exacerbation remains unclear. To identify predictive markers of COVID-19 progress and outcome, we analyzed peripheral blood of 10 COVID-19-associated ARDS patients and 35 mild/moderate COVID-19 patients, not requiring intensive care. Using multi-parametric flow cytometry, we compared quantitative, phenotypic, and functional characteristics of circulating bulk immune cells, as well as SARS-CoV-2 S-protein-reactive T cells between the two groups. ARDS patients demonstrated significantly higher S-protein-reactive CD4(+) and CD8(+) T cells compared to non-ARDS patients. Of interest, comparison of circulating bulk T cells in ARDS patients to non-ARDS patients demonstrated decreased frequencies of CD4(+) and CD8(+) T cell subsets, with activated memory/effector T cells expressing tissue migration molecule CD11a(+)(+). Importantly, survival from ARDS (4/10) was accompanied by a recovery of the CD11a(+)(+) T cell subsets in peripheral blood. Conclusively, data on S-protein-reactive polyfunctional T cells indicate the ability of ARDS patients to generate antiviral protection. Furthermore, decreased frequencies of activated memory/effector T cells expressing tissue migratory molecule CD11a(+)(+) observed in circulation of ARDS patients might suggest their involvement in ARDS development and propose the CD11a-based immune signature as a possible prognostic marker. |*Pandemics[MESH] |Adult[MESH] |Aged[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19/*immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory/*immunology[MESH] |Male[MESH] |Membrane Glycoproteins/immunology[MESH] |Middle Aged[MESH] |Respiratory Distress Syndrome/*immunology/pathology/virology[MESH] |SARS-CoV-2/immunology/pathogenicity[MESH] |T-Lymphocyte Subsets/immunology[MESH]COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activa(epmc).pdf DeepDyve Pubget Overpricing