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10.18632/aging.104024 http://scihub22266oqcxt.onion/10.18632/aging.104024 33186121!7695409!33186121     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2020 ; 12 (21): 20938-20945 Nephropedia Template TP {{tp|p=33186121|t=2020. Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses |pdf=|usr=}}{{33186121}} gab.com Text Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=33186121 #FOAvip The pandemic COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is spreading very rapidly worldwide. To date, the origin and intermediate hosts of SARS-CoV-2 remain unclear. In this study, we conducted comparative analysis among SARS-CoV-2 and non-SARS-CoV-2 coronavirus strains to elucidate their phylogenetic relationships. We found: 1, the SARS-CoV-2 strains analyzed could be divided into 3 clades with regional aggregation; 2, the non-SARS-CoV-2 common coronaviruses that infect humans or other organisms to cause respiratory syndrome and epizootic catarrhal gastroenteritis could also be divided into 3 clades; 3, the hosts of the common coronaviruses closest to SARS-CoV-2 were Apodemus chevrieri (a rodent), Delphinapterus leucas (beluga whale), Hypsugo savii (bat) , Camelus bactrianus (camel) and Mustela vison (mink); and 4, the gene sequences of the receptor ACE2 from different hosts could also be divided into 3 clades. The ACE2 gene sequences closest to that of humans in evolution include those from Nannospalax galili (Upper Galilee mountains blind mole rat), Phyllostomus discolor (pale spear-nosed bat), Mus musculus (house mouse), Delphinapterus leucas (beluga whale), and Catharus ustulatus (Swainson's thrush). We conclude that SARS-CoV-2 may have evolved from a distant common ancestor with the common coronaviruses but not a branch of any of them, implying that the prevalent pandemic COVID-19 agent SARS-CoV-2 may have existed in a yet to be identified primary host for a long time. Twit Text FOAVip Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=33186121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33186121 #FOAvip English Wikipedia <ref>{{Cite pmid|33186121}}</ref> Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses #MMPMID33186121 Li FF; Zhang Q; Wang GY; Liu SL Aging (Albany NY) 2020[Nov]; 12 (21): 20938-20945 PMID33186121show ga The pandemic COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it is spreading very rapidly worldwide. To date, the origin and intermediate hosts of SARS-CoV-2 remain unclear. In this study, we conducted comparative analysis among SARS-CoV-2 and non-SARS-CoV-2 coronavirus strains to elucidate their phylogenetic relationships. We found: 1, the SARS-CoV-2 strains analyzed could be divided into 3 clades with regional aggregation; 2, the non-SARS-CoV-2 common coronaviruses that infect humans or other organisms to cause respiratory syndrome and epizootic catarrhal gastroenteritis could also be divided into 3 clades; 3, the hosts of the common coronaviruses closest to SARS-CoV-2 were Apodemus chevrieri (a rodent), Delphinapterus leucas (beluga whale), Hypsugo savii (bat) , Camelus bactrianus (camel) and Mustela vison (mink); and 4, the gene sequences of the receptor ACE2 from different hosts could also be divided into 3 clades. The ACE2 gene sequences closest to that of humans in evolution include those from Nannospalax galili (Upper Galilee mountains blind mole rat), Phyllostomus discolor (pale spear-nosed bat), Mus musculus (house mouse), Delphinapterus leucas (beluga whale), and Catharus ustulatus (Swainson's thrush). We conclude that SARS-CoV-2 may have evolved from a distant common ancestor with the common coronaviruses but not a branch of any of them, implying that the prevalent pandemic COVID-19 agent SARS-CoV-2 may have existed in a yet to be identified primary host for a long time. |*Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |*COVID-19/physiopathology/virology[MESH] |*Coronavirus/classification/pathogenicity/physiology[MESH] |*Disease Reservoirs/classification/virology[MESH] |*SARS-CoV-2/pathogenicity/physiology[MESH] |Animals[MESH] |Gastrointestinal Diseases/virology[MESH] |Humans[MESH] |Phylogeny[MESH]Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutio(epmc).pdf DeepDyve Pubget Overpricing