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10.1111/febs.15625 http://scihub22266oqcxt.onion/10.1111/febs.15625 33185982!8359365!33185982     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2021 ; 288 (12): 3715-3726 Nephropedia Template TP {{tp|p=33185982|t=2021. Interferon-stimulated gene products as regulators of central carbon metabolism |pdf=|usr=}}{{33185982}} gab.com Text Interferon-stimulated gene products as regulators of central carbon metabolism JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33185982 #FOAvip In response to viral infections, the innate immune system rapidly activates expression of several interferon-stimulated genes (ISGs), whose protein and metabolic products are believed to directly interfere with the viral life cycle. Here, we argue that biochemical reactions performed by two specific protein products of ISGs modulate central carbon metabolism to support a broad-spectrum antiviral response. We demonstrate that the metabolites generated by metalloenzymes nitric oxide synthase and the radical S-adenosylmethionine (SAM) enzyme RSAD2 inhibit the activity of the housekeeping and glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). We discuss that this inhibition is likely to stimulate a range of metabolic and signalling processes to support a broad-spectrum immune response. Based on these analyses, we propose that inhibiting GAPDH in individuals with deteriorated cellular innate immune response like elderly might help in treating viral diseases such as COVID-19. Twit Text FOAVip Interferon-stimulated gene products as regulators of central carbon metabolism ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33185982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33185982 #FOAvip English Wikipedia <ref>{{Cite pmid|33185982}}</ref> Interferon-stimulated gene products as regulators of central carbon metabolism #MMPMID33185982 Ebrahimi KH; Gilbert-Jaramillo J; James WS; McCullagh JSO FEBS J 2021[Jun]; 288 (12): 3715-3726 PMID33185982show ga In response to viral infections, the innate immune system rapidly activates expression of several interferon-stimulated genes (ISGs), whose protein and metabolic products are believed to directly interfere with the viral life cycle. Here, we argue that biochemical reactions performed by two specific protein products of ISGs modulate central carbon metabolism to support a broad-spectrum antiviral response. We demonstrate that the metabolites generated by metalloenzymes nitric oxide synthase and the radical S-adenosylmethionine (SAM) enzyme RSAD2 inhibit the activity of the housekeeping and glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). We discuss that this inhibition is likely to stimulate a range of metabolic and signalling processes to support a broad-spectrum immune response. Based on these analyses, we propose that inhibiting GAPDH in individuals with deteriorated cellular innate immune response like elderly might help in treating viral diseases such as COVID-19. |Antiviral Agents/*metabolism/pharmacology[MESH] |COVID-19/prevention & control/virology[MESH] |Carbon/*metabolism[MESH] |Cells, Cultured[MESH] |Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunity, Innate/drug effects[MESH] |Induced Pluripotent Stem Cells/metabolism[MESH] |Interferons/*metabolism[MESH] |Macrophages/metabolism[MESH] |Models, Biological[MESH] |Oxidoreductases Acting on CH-CH Group Donors[MESH] |Proteins/genetics/*metabolism[MESH] |S-Adenosylmethionine/*metabolism[MESH] |SARS-CoV-2/drug effects/physiology[MESH]Interferon-stimulated gene products as regulators of central carbon me(epmc).pdf DeepDyve Pubget Overpricing