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10.2174/1389557520666201113105940

http://scihub22266oqcxt.onion/10.2174/1389557520666201113105940
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33185159!ä!33185159

suck abstract from ncbi


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pmid33185159      Mini+Rev+Med+Chem 2021 ; 21 (6): 704-723
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  • Drug Re-purposing Approach and Potential Therapeutic Strategies to Treat COVID-19 #MMPMID33185159
  • Reddy EK; Battula S; Anwar S; Sajith AM
  • Mini Rev Med Chem 2021[]; 21 (6): 704-723 PMID33185159show ga
  • The current pandemic of COVID-19 caused by SARS-Cov-2 has posed a severe threat to the whole world with its highly infectious, progressive nature with up to 10% mortality rates. The severity of the situation faced by the whole world and the lack of efficient therapeutics to treat this viral disease have led the WHO to depend on the drug-repurposing approach to tackle this major global health problem. This review aims at highlighting the various synthetic approaches employed for the synthesis of these FDA approved drugs that have been presently used for COVID-19 treatment. Additionally, a brief overview of several therapeutic strategies is also presented. This review will encourage the scientific community across the globe to come up with better and efficient synthetic protocols and also novel chemical entities along with this core with more potent activity.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antiviral Agents/chemical synthesis/chemistry/*pharmacology/therapeutic use[MESH]
  • |Azetidines/chemical synthesis/chemistry/pharmacology/therapeutic use[MESH]
  • |Chemistry Techniques, Synthetic/methods[MESH]
  • |Drug Repositioning/*methods[MESH]
  • |Humans[MESH]
  • |Nitriles[MESH]
  • |Purines/chemical synthesis/chemistry/pharmacology/therapeutic use[MESH]
  • |Pyrazoles/chemical synthesis/chemistry/pharmacology/therapeutic use[MESH]
  • |Pyrimidines[MESH]
  • |SARS-CoV-2/*drug effects/physiology[MESH]
  • |Sulfonamides/chemical synthesis/chemistry/pharmacology/therapeutic use[MESH]


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