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10.1038/s41591-020-01143-2 http://scihub22266oqcxt.onion/10.1038/s41591-020-01143-2 33184509!ä!33184509 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33184509.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2021 ; 27 (1): 78-85 Nephropedia Template TP {{tp|p=33184509|t=2021. Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells |pdf=|usr=}}{{33184509}} gab.com Text Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33184509 #FOAvip Emerging data indicate that SARS-CoV-2-specific CD8(+) T cells targeting different viral proteins are detectable in up to 70% of convalescent individuals(1-5). However, very little information is currently available about the abundance, phenotype, functional capacity and fate of pre-existing and induced SARS-CoV-2-specific CD8(+) T cell responses during the natural course of SARS-CoV-2 infection. Here, we define a set of optimal and dominant SARS-CoV-2-specific CD8(+) T cell epitopes. We also perform a high-resolution ex vivo analysis of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells, applying peptide-loaded major histocompatibility complex class I (pMHCI) tetramer technology. We observe rapid induction, prolonged contraction and emergence of heterogeneous and functionally competent cross-reactive and induced memory CD8(+) T cell responses in cross-sectionally analyzed individuals with mild disease following SARS-CoV-2 infection and three individuals longitudinally assessed for their T cells pre- and post-SARS-CoV-2 infection. SARS-CoV-2-specific memory CD8(+) T cells exhibited functional characteristics comparable to influenza-specific CD8(+) T cells and were detectable in SARS-CoV-2 convalescent individuals who were seronegative for anti-SARS-CoV-2 antibodies targeting spike (S) and nucleoprotein (N). These results define cross-reactive and induced SARS-CoV-2-specific CD8(+) T cell responses as potentially important determinants of immune protection in mild SARS-CoV-2 infection. Twit Text FOAVip Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33184509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33184509 #FOAvip English Wikipedia <ref>{{Cite pmid|33184509}}</ref> Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells #MMPMID33184509 Schulien I; Kemming J; Oberhardt V; Wild K; Seidel LM; Killmer S; Sagar; Daul F; Salvat Lago M; Decker A; Luxenburger H; Binder B; Bettinger D; Sogukpinar O; Rieg S; Panning M; Huzly D; Schwemmle M; Kochs G; Waller CF; Nieters A; Duerschmied D; Emmerich F; Mei HE; Schulz AR; Llewellyn-Lacey S; Price DA; Boettler T; Bengsch B; Thimme R; Hofmann M; Neumann-Haefelin C Nat Med 2021[Jan]; 27 (1): 78-85 PMID33184509show ga Emerging data indicate that SARS-CoV-2-specific CD8(+) T cells targeting different viral proteins are detectable in up to 70% of convalescent individuals(1-5). However, very little information is currently available about the abundance, phenotype, functional capacity and fate of pre-existing and induced SARS-CoV-2-specific CD8(+) T cell responses during the natural course of SARS-CoV-2 infection. Here, we define a set of optimal and dominant SARS-CoV-2-specific CD8(+) T cell epitopes. We also perform a high-resolution ex vivo analysis of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells, applying peptide-loaded major histocompatibility complex class I (pMHCI) tetramer technology. We observe rapid induction, prolonged contraction and emergence of heterogeneous and functionally competent cross-reactive and induced memory CD8(+) T cell responses in cross-sectionally analyzed individuals with mild disease following SARS-CoV-2 infection and three individuals longitudinally assessed for their T cells pre- and post-SARS-CoV-2 infection. SARS-CoV-2-specific memory CD8(+) T cells exhibited functional characteristics comparable to influenza-specific CD8(+) T cells and were detectable in SARS-CoV-2 convalescent individuals who were seronegative for anti-SARS-CoV-2 antibodies targeting spike (S) and nucleoprotein (N). These results define cross-reactive and induced SARS-CoV-2-specific CD8(+) T cell responses as potentially important determinants of immune protection in mild SARS-CoV-2 infection. |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/blood/*immunology[MESH] |Case-Control Studies[MESH] |Convalescence[MESH] |Coronavirus Nucleocapsid Proteins/chemistry[MESH] |Cross Reactions[MESH] |Cross-Sectional Studies[MESH] |Epitopes, T-Lymphocyte[MESH] |Flow Cytometry[MESH] |HLA-B Antigens/immunology[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Longitudinal Studies[MESH] |Phosphoproteins/chemistry[MESH] |SARS-CoV-2/physiology[MESH]Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+(epmc).pdf DeepDyve Pubget Overpricing