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10.1126/science.abe8499

http://scihub22266oqcxt.onion/10.1126/science.abe8499
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33184236!7775736!33184236
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suck abstract from ncbi


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pmid33184236      Science 2020 ; 370 (6523): 1464-1468
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  • SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo #MMPMID33184236
  • Hou YJ; Chiba S; Halfmann P; Ehre C; Kuroda M; Dinnon KH 3rd; Leist SR; Schafer A; Nakajima N; Takahashi K; Lee RE; Mascenik TM; Graham R; Edwards CE; Tse LV; Okuda K; Markmann AJ; Bartelt L; de Silva A; Margolis DM; Boucher RC; Randell SH; Suzuki T; Gralinski LE; Kawaoka Y; Baric RS
  • Science 2020[Dec]; 370 (6523): 1464-1468 PMID33184236show ga
  • The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral pathogenesis and transmissibility remain unclear. We engineered a SARS-CoV-2 variant containing this substitution. The variant exhibits more efficient infection, replication, and competitive fitness in primary human airway epithelial cells but maintains similar morphology and in vitro neutralization properties, compared with the ancestral wild-type virus. Infection of human angiotensin-converting enzyme 2 (ACE2) transgenic mice and Syrian hamsters with both viruses resulted in similar viral titers in respiratory tissues and pulmonary disease. However, the D614G variant transmits significantly faster and displayed increased competitive fitness than the wild-type virus in hamsters. These data show that the D614G substitution enhances SARS-CoV-2 infectivity, competitive fitness, and transmission in primary human cells and animal models.
  • |Amino Acid Substitution[MESH]
  • |Angiotensin-Converting Enzyme 2/genetics[MESH]
  • |Animals[MESH]
  • |Asparagine/genetics[MESH]
  • |COVID-19/*transmission/*virology[MESH]
  • |Cricetinae[MESH]
  • |Genetic Fitness/genetics[MESH]
  • |Glycine/genetics[MESH]
  • |Humans[MESH]
  • |Mesocricetus[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Respiratory Mucosa/virology[MESH]
  • |SARS-CoV-2/*genetics/*pathogenicity[MESH]
  • |Virulence/genetics[MESH]


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