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10.1073/pnas.2012939117 http://scihub22266oqcxt.onion/10.1073/pnas.2012939117 33184176!7720140!33184176     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (48): 30687-30698 Nephropedia Template TP {{tp|p=33184176|t=2020. The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses |pdf=|usr=}}{{33184176}} gab.com Text The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=33184176 #FOAvip The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals. We present work that the mammalian SKI complex is a broad-spectrum, host-directed, antiviral drug target. Yeast suppressor screening was utilized to find a functional genetic interaction between proteins from influenza A virus (IAV) and Middle East respiratory syndrome coronavirus (MERS-CoV) with eukaryotic proteins that may be potential host factors involved in replication. This screening identified the SKI complex as a potential host factor for both viruses. In mammalian systems siRNA-mediated knockdown of SKI genes inhibited replication of IAV and MERS-CoV. In silico modeling and database screening identified a binding pocket on the SKI complex and compounds predicted to bind. Experimental assays of those compounds identified three chemical structures that were antiviral against IAV and MERS-CoV along with the filoviruses Ebola and Marburg and two further coronaviruses, SARS-CoV and SARS-CoV-2. The mechanism of antiviral activity is through inhibition of viral RNA production. This work defines the mammalian SKI complex as a broad-spectrum antiviral drug target and identifies lead compounds for further development. Twit Text FOAVip The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=33184176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33184176 #FOAvip English Wikipedia <ref>{{Cite pmid|33184176}}</ref> The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses #MMPMID33184176 Weston S; Baracco L; Keller C; Matthews K; McGrath ME; Logue J; Liang J; Dyall J; Holbrook MR; Hensley LE; Jahrling PB; Yu W; MacKerell AD Jr; Frieman MB Proc Natl Acad Sci U S A 2020[Dec]; 117 (48): 30687-30698 PMID33184176show ga The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals. We present work that the mammalian SKI complex is a broad-spectrum, host-directed, antiviral drug target. Yeast suppressor screening was utilized to find a functional genetic interaction between proteins from influenza A virus (IAV) and Middle East respiratory syndrome coronavirus (MERS-CoV) with eukaryotic proteins that may be potential host factors involved in replication. This screening identified the SKI complex as a potential host factor for both viruses. In mammalian systems siRNA-mediated knockdown of SKI genes inhibited replication of IAV and MERS-CoV. In silico modeling and database screening identified a binding pocket on the SKI complex and compounds predicted to bind. Experimental assays of those compounds identified three chemical structures that were antiviral against IAV and MERS-CoV along with the filoviruses Ebola and Marburg and two further coronaviruses, SARS-CoV and SARS-CoV-2. The mechanism of antiviral activity is through inhibition of viral RNA production. This work defines the mammalian SKI complex as a broad-spectrum antiviral drug target and identifies lead compounds for further development. |Antiviral Agents/*pharmacology[MESH] |Cell Line[MESH] |Coronavirus/*drug effects[MESH] |Filoviridae/*drug effects[MESH] |Genes, Suppressor[MESH] |Host-Pathogen Interactions/*drug effects[MESH] |Models, Molecular[MESH] |Molecular Targeted Therapy[MESH] |Multiprotein Complexes/*metabolism[MESH] |Orthomyxoviridae/*drug effects[MESH] |Protein Binding[MESH] |RNA, Small Interfering/metabolism[MESH] |RNA, Viral/genetics/metabolism[MESH] |Saccharomyces cerevisiae/genetics[MESH] |Viral Proteins/metabolism[MESH]The SKI complex is a broad-spectrum, host-directed antiviral drug targ(epmc).pdf DeepDyve Pubget Overpricing