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10.1128/mBio.02374-20 http://scihub22266oqcxt.onion/10.1128/mBio.02374-20 33184103!7663010!33184103     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       mBio 2020 ; 11 (6): ä Nephropedia Template TP {{tp|p=33184103|t=2020. Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2 |pdf=|usr=}}{{33184103}} gab.com Text Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2 JO: mBio http://www.kidney.de/pget.php?&tw=1&pmid=33184103 #FOAvip Mucus plays a pivotal role in protecting the respiratory tract against microbial infections. It acts as a primary contact site to entrap microbes and facilitates their removal from the respiratory tract via the coordinated beating of motile cilia. The major components of airway mucus are heavily O-glycosylated mucin glycoproteins, divided into gel-forming mucins and transmembrane mucins. The gel-forming mucins MUC5AC and MUC5B are the primary structural components of airway mucus, and they enable efficient clearance of pathogens by mucociliary clearance. MUC5B is constitutively expressed in the healthy airway, whereas MUC5AC is upregulated in response to inflammatory challenge. MUC1, MUC4, and MUC16 are the three major transmembrane mucins of the respiratory tracts which prevent microbial invasion, can act as releasable decoy receptors, and activate intracellular signal transduction pathways. Pathogens have evolved virulence factors such as adhesins that facilitate interaction with specific mucins and mucin glycans, for example, terminal sialic acids. Mucin expression and glycosylation are dependent on the inflammatory state of the respiratory tract and are directly regulated by proinflammatory cytokines and microbial ligands. Gender and age also impact mucin glycosylation and expression through the female sex hormone estradiol and age-related downregulation of mucin production. Here, we discuss what is currently known about the role of respiratory mucins and their glycans during bacterial and viral infections of the airways and their relevance for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding the impact of microbe-mucin interaction in the respiratory tract could inspire the development of novel therapies to boost mucosal defense and combat respiratory infections. Twit Text FOAVip Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2 ????mBio http://www.kidney.de/pget.php?&tw=1&pmid=33184103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33184103 #FOAvip English Wikipedia <ref>{{Cite pmid|33184103}}</ref> Defensive Properties of Mucin Glycoproteins during Respiratory Infections-Relevance for SARS-CoV-2 #MMPMID33184103 Chatterjee M; van Putten JPM; Strijbis K mBio 2020[Nov]; 11 (6): ä PMID33184103show ga Mucus plays a pivotal role in protecting the respiratory tract against microbial infections. It acts as a primary contact site to entrap microbes and facilitates their removal from the respiratory tract via the coordinated beating of motile cilia. The major components of airway mucus are heavily O-glycosylated mucin glycoproteins, divided into gel-forming mucins and transmembrane mucins. The gel-forming mucins MUC5AC and MUC5B are the primary structural components of airway mucus, and they enable efficient clearance of pathogens by mucociliary clearance. MUC5B is constitutively expressed in the healthy airway, whereas MUC5AC is upregulated in response to inflammatory challenge. MUC1, MUC4, and MUC16 are the three major transmembrane mucins of the respiratory tracts which prevent microbial invasion, can act as releasable decoy receptors, and activate intracellular signal transduction pathways. Pathogens have evolved virulence factors such as adhesins that facilitate interaction with specific mucins and mucin glycans, for example, terminal sialic acids. Mucin expression and glycosylation are dependent on the inflammatory state of the respiratory tract and are directly regulated by proinflammatory cytokines and microbial ligands. Gender and age also impact mucin glycosylation and expression through the female sex hormone estradiol and age-related downregulation of mucin production. Here, we discuss what is currently known about the role of respiratory mucins and their glycans during bacterial and viral infections of the airways and their relevance for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding the impact of microbe-mucin interaction in the respiratory tract could inspire the development of novel therapies to boost mucosal defense and combat respiratory infections. |Bacterial Infections/metabolism[MESH] |COVID-19/virology[MESH] |Glycoproteins/*metabolism[MESH] |Glycosylation[MESH] |Humans[MESH] |Mucin 5AC/metabolism[MESH] |Mucin-1/metabolism[MESH] |Mucin-5B/metabolism[MESH] |Mucins/*metabolism[MESH] |Respiratory Tract Infections/*microbiology/prevention & control/*virology[MESH] |SARS-CoV-2/pathogenicity[MESH]Defensive Properties of Mucin Glycoproteins during Respiratory Infect(epmc).pdf DeepDyve Pubget Overpricing