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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Pediatr+Rev 2021 ; 17 (1): 38-44 Nephropedia Template TP
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COVID-19 and Comorbidities: Is Inflammation the Underlying Condition in Children? A Narrative Review #MMPMID33183207
Pinna G; Sanfilippo L; Bassareo PP; Fanos V; Marcialis MA
Curr Pediatr Rev 2021[]; 17 (1): 38-44 PMID33183207show ga
This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have, therefore, been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.