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10.1016/j.intimp.2020.106995 http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.106995 33182059!7486051!33182059     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33182059&cmd=llinks): Failed to open stream: HTTP request failed! 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Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D |pdf=|usr=}}{{33182059}} gab.com Text Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33182059 #FOAvip There is recent evidence that interleukin-6 (IL-6) levels are elevated in cases of complicated COVID-19, but it is also possible that this cytokine may have a far more important role in the pathogenesis of viral infection. IL-6 is known to be modulated by Vitamin D, and there is preliminary evidence that deficiency of this vitamin is linked to poorer outcomes. To identify whether IL-6 levels prior to infection might predict outcome, early data on COVID-19 mortality from Italy and the UK were compared with previously published results of mean IL-6 levels from these countries as well as from the USA. There was a highly significant correlation (r = 0.9883; p = 0.00025) between age-stratified mortality rates and IL-6 levels from previously published data on healthy individuals. To determine whether Vitamin D may be beneficial at lowering IL-6 levels in patients, a limited analysis of trials examining the relationship between these entities published since 2015 was undertaken. Eight out of 11 studies described a significant lowering effect of Vitamin D on IL-6. Given that IL-6 likely facilitates viral cell entry and replication, levels prior to infection may predict mortality. This provides a rationale for prophylactic and therapeutic measures directed at lowering IL-6, including Vitamin D prescription. Twit Text FOAVip Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33182059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33182059 #FOAvip English Wikipedia <ref>{{Cite pmid|33182059}}</ref> Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role for Vitamin D #MMPMID33182059 Silberstein M Int Immunopharmacol 2020[Nov]; 88 (ä): 106995 PMID33182059show ga There is recent evidence that interleukin-6 (IL-6) levels are elevated in cases of complicated COVID-19, but it is also possible that this cytokine may have a far more important role in the pathogenesis of viral infection. IL-6 is known to be modulated by Vitamin D, and there is preliminary evidence that deficiency of this vitamin is linked to poorer outcomes. To identify whether IL-6 levels prior to infection might predict outcome, early data on COVID-19 mortality from Italy and the UK were compared with previously published results of mean IL-6 levels from these countries as well as from the USA. There was a highly significant correlation (r = 0.9883; p = 0.00025) between age-stratified mortality rates and IL-6 levels from previously published data on healthy individuals. To determine whether Vitamin D may be beneficial at lowering IL-6 levels in patients, a limited analysis of trials examining the relationship between these entities published since 2015 was undertaken. Eight out of 11 studies described a significant lowering effect of Vitamin D on IL-6. Given that IL-6 likely facilitates viral cell entry and replication, levels prior to infection may predict mortality. This provides a rationale for prophylactic and therapeutic measures directed at lowering IL-6, including Vitamin D prescription. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19[MESH] |Coronavirus Infections/*blood/drug therapy/epidemiology/*mortality[MESH] |Female[MESH] |Humans[MESH] |Interleukin-6/*blood[MESH] |Italy/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*blood/drug therapy/epidemiology/*mortality[MESH] |United Kingdom/epidemiology[MESH] |Vitamin D/*therapeutic use[MESH] |Vitamins/*therapeutic use[MESH]Correlation between premorbid IL-6 levels and COVID-19 mortality: Pote(epmc).pdf DeepDyve Pubget Overpricing