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10.1016/j.phrs.2020.105297 http://scihub22266oqcxt.onion/10.1016/j.phrs.2020.105297 33181319!7962892!33181319     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacol+Res 2021 ; 163 (ä): 105297 Nephropedia Template TP {{tp|p=33181319|t=2021. Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications |pdf=|usr=}}{{33181319}} gab.com Text Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications JO: Pharmacol Res http://www.kidney.de/pget.php?&tw=1&pmid=33181319 #FOAvip Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in various diseases, including inflammatory diseases, cardiovascular diseases and neurological diseases. However, the potential of Nec-1 in diseases has not received much attention. Nec-1 is able to inhibit necroptosis signaling pathway and thus ameliorate necroptotic cell death in disease development. Recent research findings indicate that Nec-1 could be applied in several types of diseases to alleviate disease development or improve prognosis. Moreover, we predict that Nec-1 has the potential to protect against the complications of coronavirus disease 2019 (COVID-19). This review summarized the effect of Nec-1 in disease models and the underlying molecular mechanism, providing research evidence for its future application. Twit Text FOAVip Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications ????Pharmacol Res http://www.kidney.de/pget.php?&tw=1&pmid=33181319 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33181319 #FOAvip English Wikipedia <ref>{{Cite pmid|33181319}}</ref> Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications #MMPMID33181319 Cao L; Mu W Pharmacol Res 2021[Jan]; 163 (ä): 105297 PMID33181319show ga Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in various diseases, including inflammatory diseases, cardiovascular diseases and neurological diseases. However, the potential of Nec-1 in diseases has not received much attention. Nec-1 is able to inhibit necroptosis signaling pathway and thus ameliorate necroptotic cell death in disease development. Recent research findings indicate that Nec-1 could be applied in several types of diseases to alleviate disease development or improve prognosis. Moreover, we predict that Nec-1 has the potential to protect against the complications of coronavirus disease 2019 (COVID-19). This review summarized the effect of Nec-1 in disease models and the underlying molecular mechanism, providing research evidence for its future application. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |COVID-19/metabolism/pathology/virology[MESH] |Disease Models, Animal[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Imidazoles/metabolism/*pharmacology[MESH] |Indoles/metabolism/*pharmacology[MESH] |Lung/*drug effects/metabolism/pathology/virology[MESH] |Necroptosis/*drug effects[MESH] |SARS-CoV-2/*pathogenicity[MESH]Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeu(epmc).pdf DeepDyve Pubget Overpricing