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10.1016/j.cbi.2020.109309 http://scihub22266oqcxt.onion/10.1016/j.cbi.2020.109309 33181114!7649659!33181114     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33181114&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Biol+Interact 2020 ; 332 (ä): 109309 Nephropedia Template TP {{tp|p=33181114|t=2020. In silico analysis of selected alkaloids against main protease (M(pro)) of SARS-CoV-2 |pdf=|usr=}}{{33181114}} gab.com Text In silico analysis of selected alkaloids against main protease (M(pro)) of SARS-CoV-2 JO: Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=33181114 #FOAvip In the present situation, COVID-19 has become the global health concern due to its high contagious nature. It initially appeared in December 2019 in Wuhan, China and now affected more than 190 countries. As of now preventive measures are the sole solution to stop this disease for further transmission from person to person transmissions as there is no effective treatment or vaccine available to date. Research and development of new molecule is a laborious process; therefore, drug repurposing can be an alternative solution that involves the identification of potential compounds from the already available data. Alkaloids are potential source of therapeutic agents which might be able to treat novel COVID-19. Therefore, in the present study, twenty potential alkaloid molecules that possess antiviral activity against different viral diseases have taken into consideration and scrutinized using Lipinski's rule. Then out of twenty compounds seventeen were further selected for docking study. Docking study was performed using Autodock software and the best four molecule which provides maximum negative binding energy was selected for further analysis. Two alkaloids namely thalimonine and sophaline D showed potential activity to inhibit the M(pro) but to confirm the claim further in-vitro studies are required. Twit Text FOAVip In silico analysis of selected alkaloids against main protease (M(pro)) of SARS-CoV-2 ????Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=33181114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33181114 #FOAvip English Wikipedia <ref>{{Cite pmid|33181114}}</ref> In silico analysis of selected alkaloids against main protease (M(pro)) of SARS-CoV-2 #MMPMID33181114 Garg S; Roy A Chem Biol Interact 2020[Dec]; 332 (ä): 109309 PMID33181114show ga In the present situation, COVID-19 has become the global health concern due to its high contagious nature. It initially appeared in December 2019 in Wuhan, China and now affected more than 190 countries. As of now preventive measures are the sole solution to stop this disease for further transmission from person to person transmissions as there is no effective treatment or vaccine available to date. Research and development of new molecule is a laborious process; therefore, drug repurposing can be an alternative solution that involves the identification of potential compounds from the already available data. Alkaloids are potential source of therapeutic agents which might be able to treat novel COVID-19. Therefore, in the present study, twenty potential alkaloid molecules that possess antiviral activity against different viral diseases have taken into consideration and scrutinized using Lipinski's rule. Then out of twenty compounds seventeen were further selected for docking study. Docking study was performed using Autodock software and the best four molecule which provides maximum negative binding energy was selected for further analysis. Two alkaloids namely thalimonine and sophaline D showed potential activity to inhibit the M(pro) but to confirm the claim further in-vitro studies are required. |Alkaloids/chemistry/*metabolism[MESH] |Antiviral Agents/chemistry/*metabolism[MESH] |Catalytic Domain[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors/chemistry/metabolism[MESH] |Cysteine Proteinase Inhibitors/chemistry/*metabolism[MESH] |Ligands[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Protein Binding[MESH] |Protein Structure, Secondary/drug effects[MESH]In silico analysis of selected alkaloids against main protease (M(pro)(epmc).pdf DeepDyve Pubget Overpricing