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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 PLoS+Pathog 2020 ; 16 (11): e1008949 Nephropedia Template TP
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Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression #MMPMID33180882
Zheng H; Li H; Guo L; Liang Y; Li J; Wang X; Hu Y; Wang L; Liao Y; Yang F; Li Y; Fan S; Li D; Cui P; Wang Q; Shi H; Chen Y; Yang Z; Yang J; Shen D; Cun W; Zhou X; Dong X; Wang Y; Chen Y; Dai Q; Jin W; He Z; Li Q; Liu L
PLoS Pathog 2020[Nov]; 16 (11): e1008949 PMID33180882show ga
The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally. To better understand the pathogenesis caused by SARS-CoV-2, we developed a rhesus macaque model to mimic natural infection via the nasal route, resulting in the SARS-CoV-2 virus shedding in the nose and stool up to 27 days. Importantly, we observed the pathological progression of marked interstitial pneumonia in the infected animals on 5-7 dpi, with virus dissemination widely occurring in the lower respiratory tract and lymph nodes, and viral RNA was consistently detected from 5 to 21 dpi. During the infection period, the kinetics response of T cells was revealed to contribute to COVID-19 progression. Our findings implied that the antiviral response of T cells was suppressed after 3 days post infection, which might be related to increases in the Treg cell population in PBMCs. Moreover, two waves of the enhanced production of cytokines (TGF-alpha, IL-4, IL-6, GM-CSF, IL-10, IL-15, IL-1beta), chemokines (MCP-1/CCL2, IL-8/CXCL8, and MIP-1beta/CCL4) were detected in lung tissue. Our data collected from this model suggested that T cell response and cytokine/chemokine changes in lung should be considered as evaluation parameters for COVID-19 treatment and vaccine development, besides of observation of virus shedding and pathological analysis.