Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/JCI140766 http://scihub22266oqcxt.onion/10.1172/JCI140766 33180746!7773394!33180746     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (1): ä Nephropedia Template TP {{tp|p=33180746|t=2021. Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium |pdf=|usr=}}{{33180746}} gab.com Text Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33180746 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) novel coronavirus 2019 (COVID-19) global pandemic has led to millions of cases and hundreds of thousands of deaths. While older adults appear at high risk for severe disease, hospitalizations and deaths due to SARS-CoV-2 among children have been relatively rare. Integrating single-cell RNA sequencing (scRNA-seq) of developing mouse lung with temporally resolved immunofluorescence in mouse and human lung tissue, we found that expression of SARS-CoV-2 Spike protein primer TMPRSS2 was highest in ciliated cells and type I alveolar epithelial cells (AT1), and TMPRSS2 expression increased with aging in mice and humans. Analysis of autopsy tissue from fatal COVID-19 cases detected SARS-CoV-2 RNA most frequently in ciliated and secretory cells in airway epithelium and AT1 cells in peripheral lung. SARS-CoV-2 RNA was highly colocalized in cells expressing TMPRSS2. Together, these data demonstrate the cellular spectrum infected by SARS-CoV-2 in lung epithelium and suggest that developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness. Twit Text FOAVip Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33180746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33180746 #FOAvip English Wikipedia <ref>{{Cite pmid|33180746}}</ref> Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium #MMPMID33180746 Schuler BA; Habermann AC; Plosa EJ; Taylor CJ; Jetter C; Negretti NM; Kapp ME; Benjamin JT; Gulleman P; Nichols DS; Braunstein LZ; Hackett A; Koval M; Guttentag SH; Blackwell TS; Webber SA; Banovich NE; Kropski JA; Sucre JM J Clin Invest 2021[Jan]; 131 (1): ä PMID33180746show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) novel coronavirus 2019 (COVID-19) global pandemic has led to millions of cases and hundreds of thousands of deaths. While older adults appear at high risk for severe disease, hospitalizations and deaths due to SARS-CoV-2 among children have been relatively rare. Integrating single-cell RNA sequencing (scRNA-seq) of developing mouse lung with temporally resolved immunofluorescence in mouse and human lung tissue, we found that expression of SARS-CoV-2 Spike protein primer TMPRSS2 was highest in ciliated cells and type I alveolar epithelial cells (AT1), and TMPRSS2 expression increased with aging in mice and humans. Analysis of autopsy tissue from fatal COVID-19 cases detected SARS-CoV-2 RNA most frequently in ciliated and secretory cells in airway epithelium and AT1 cells in peripheral lung. SARS-CoV-2 RNA was highly colocalized in cells expressing TMPRSS2. Together, these data demonstrate the cellular spectrum infected by SARS-CoV-2 in lung epithelium and suggest that developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness. |*Gene Expression Regulation, Enzymologic[MESH] |Adult[MESH] |Aging[MESH] |Alveolar Epithelial Cells/*enzymology/pathology/virology[MESH] |Animals[MESH] |COVID-19/*enzymology/*metabolism/pathology[MESH] |Child, Preschool[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH] |Mice[MESH] |SARS-CoV-2/*metabolism[MESH]Age-determined expression of priming protease TMPRSS2 and localization(epmc).pdf DeepDyve Pubget Overpricing