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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Infect+Dis 2020 ; 6 (12): 3104-3108 Nephropedia Template TP
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COVID-19 in the Developing World: Is the Immune Response to alpha-Gal an Overlooked Factor Mitigating the Severity of Infection? #MMPMID33180463
Hodzic A; de la Fuente J; Cabezas-Cruz A
ACS Infect Dis 2020[Dec]; 6 (12): 3104-3108 PMID33180463show ga
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has affected millions of people worldwide. Considerably lower prevalence and fatality rates resulting from COVID-19 are reported in Africa and Asia than in the industrialized world. In this Viewpoint, we discuss the possibility that this intriguing phenomenon could be, among other factors, due to protective immunity of the oligosaccharide galactose-alpha-1,3-galactose (alpha-Gal). The alpha-Gal immunity induced by gut microbiota that express the same glycan modification may prevent COVID-19 through the activation of different mechanisms involved in SARS-CoV-2 neutralization and the downregulation of the inflammatory response in the lungs of infected patients.