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10.1038/s41467-020-19545-8 http://scihub22266oqcxt.onion/10.1038/s41467-020-19545-8 33177504!7658256!33177504     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 5703 Nephropedia Template TP {{tp|p=33177504|t=2020. Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19 |pdf=|usr=}}{{33177504}} gab.com Text Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33177504 #FOAvip Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. Using a systems serology approach, we demonstrate higher levels of SARS-CoV-2-specific antibody features of these family members compared to healthy controls. These data indicate that children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. Relying on routine virological and serological testing may not identify exposed children, with implications for epidemiological and clinical studies across the life-span. Twit Text FOAVip Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33177504 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33177504 #FOAvip English Wikipedia <ref>{{Cite pmid|33177504}}</ref> Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19 #MMPMID33177504 Tosif S; Neeland MR; Sutton P; Licciardi PV; Sarkar S; Selva KJ; Do LAH; Donato C; Quan Toh Z; Higgins R; Van de Sandt C; Lemke MM; Lee CY; Shoffner SK; Flanagan KL; Arnold KB; Mordant FL; Mulholland K; Bines J; Dohle K; Pellicci DG; Curtis N; McNab S; Steer A; Saffery R; Subbarao K; Chung AW; Kedzierska K; Burgner DP; Crawford NW Nat Commun 2020[Nov]; 11 (1): 5703 PMID33177504show ga Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected, predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. Using a systems serology approach, we demonstrate higher levels of SARS-CoV-2-specific antibody features of these family members compared to healthy controls. These data indicate that children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. Relying on routine virological and serological testing may not identify exposed children, with implications for epidemiological and clinical studies across the life-span. |Adult[MESH] |Antibodies, Viral/*blood/immunology[MESH] |Australia[MESH] |Betacoronavirus/*immunology[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |CD8-Positive T-Lymphocytes/immunology[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Coronavirus Infections/immunology/*transmission[MESH] |Cytokines/*blood[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/blood/immunology[MESH] |Immunoglobulin G/blood/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/immunology[MESH] |Pandemics[MESH] |Parents[MESH] |Pneumonia, Viral/immunology/*transmission[MESH] |SARS-CoV-2[MESH] |Saliva/*immunology[MESH] |Serologic Tests[MESH]Immune responses to SARS-CoV-2 in three children of parents with sympt(epmc).pdf DeepDyve Pubget Overpricing