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10.1016/j.coviro.2020.10.001 http://scihub22266oqcxt.onion/10.1016/j.coviro.2020.10.001 33176273!7959698!33176273     free     free     free       Curr+Opin+Virol 2021 ; 46 (ä): 59-64 Nephropedia Template TP {{tp|p=33176273|t=2021. Detection of viruses by inflammasomes |pdf=|usr=}}{{33176273}} gab.com Text Detection of viruses by inflammasomes JO: Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=33176273 #FOAvip The innate immune system has evolved mechanisms to keep the viral infection under control and repair damaged tissues. Several pathways can identify the presence of pathogenic components, such as viral nucleic acids and viral proteins. Also, the innate immune system can detect cellular and tissue perturbations caused by infections. Inflammasomes are cellular pieces of machinery that can detect a pathogen's presence and its possible impact on cellular integrity. Thereby several inflammasomes, including the NLRP3 inflammasome and the AIM2 inflammasome, contribute to antiviral innate immunity. Inflammation driven by inflammasomes promotes immune defenses and initiate repair mechanisms. However, its overactivation may trigger acute inflammatory responses that may harm the host. This pathologic activation could contribute to the hyperinflammatory response observed in patients infected with viruses, including influenza, SARS, and possibly SARS-CoV2. Twit Text FOAVip Detection of viruses by inflammasomes ????Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=33176273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33176273 #FOAvip English Wikipedia <ref>{{Cite pmid|33176273}}</ref> Detection of viruses by inflammasomes #MMPMID33176273 Spel L; Martinon F Curr Opin Virol 2021[Feb]; 46 (ä): 59-64 PMID33176273show ga The innate immune system has evolved mechanisms to keep the viral infection under control and repair damaged tissues. Several pathways can identify the presence of pathogenic components, such as viral nucleic acids and viral proteins. Also, the innate immune system can detect cellular and tissue perturbations caused by infections. Inflammasomes are cellular pieces of machinery that can detect a pathogen's presence and its possible impact on cellular integrity. Thereby several inflammasomes, including the NLRP3 inflammasome and the AIM2 inflammasome, contribute to antiviral innate immunity. Inflammation driven by inflammasomes promotes immune defenses and initiate repair mechanisms. However, its overactivation may trigger acute inflammatory responses that may harm the host. This pathologic activation could contribute to the hyperinflammatory response observed in patients infected with viruses, including influenza, SARS, and possibly SARS-CoV2. |*Immunity, Innate[MESH] |Animals[MESH] |Genome, Viral[MESH] |Humans[MESH] |Inflammasomes/*immunology/metabolism[MESH] |Viral Proteins/metabolism[MESH] |Viroporin Proteins/metabolism[MESH] |Virus Diseases/*immunology/virology[MESH]Detection of viruses by inflammasomes (epmc).pdf DeepDyve Pubget Overpricing