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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Infect+Dis 2021 ; 223 (1): 62-71 Nephropedia Template TP
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SARS-CoV-2 Seroprevalence and Antibody Kinetics Among Health Care Workers in a Spanish Hospital After 3 Months of Follow-up #MMPMID33175145
Moncunill G; Mayor A; Santano R; Jimenez A; Vidal M; Tortajada M; Sanz S; Mendez S; Llupia A; Aguilar R; Alonso S; Barrios D; Carolis C; Cistero P; Choliz E; Cruz A; Fochs S; Jairoce C; Hecht J; Lamoglia M; Martinez MJ; Moreno J; Mitchell RA; Ortega N; Pey N; Puyol L; Ribes M; Rosell N; Figueroa-Romero A; Sotomayor P; Torres S; Williams S; Barroso S; Vilella A; Trilla A; Varela P; Dobano C; Garcia-Basteiro AL
J Infect Dis 2021[Jan]; 223 (1): 62-71 PMID33175145show ga
BACKGROUND: At the COVID-19 spring 2020 pandemic peak in Spain, prevalence of SARS-CoV-2 infection in a cohort of 578 randomly selected health care workers (HCWs) from Hospital Clinic de Barcelona was 11.2%. METHODS: A follow-up survey 1 month later (April-May 2020) measured infection by rRT-PCR and IgM, IgA, and IgG to the receptor-binding domain of the spike protein by Luminex. Antibody kinetics, including IgG subclasses, was assessed until month 3. RESULTS: At month 1, the prevalence of infection measured by rRT-PCR and serology was 14.9% (84/565) and seroprevalence 14.5% (82/565). We found 25 (5%) new infections in 501 participants without previous evidence of infection. IgM, IgG, and IgA levels declined in 3 months (antibody decay rates 0.15 [95% CI, .11-.19], 0.66 [95% CI, .54-.82], and 0.12 [95% CI, .09-.16], respectively), and 68.33% of HCWs had seroreverted for IgM, 3.08% for IgG, and 24.29% for IgA. The most frequent subclass responses were IgG1 (highest levels) and IgG2, followed by IgG3, and only IgA1 but no IgA2 was detected. CONCLUSIONS: Continuous and improved surveillance of SARS-CoV-2 infections in HCWs remains critical, particularly in high-risk groups. The observed fast decay of IgA and IgM levels has implications for seroprevalence studies using these isotypes.