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10.1101/2020.11.03.367516 http://scihub22266oqcxt.onion/10.1101/2020.11.03.367516 33173862!7654850!33173862     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       bioRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=33173862|t=2021. The translational landscape of SARS-CoV-2 and infected cells |pdf=|usr=}}{{33173862}} gab.com Text The translational landscape of SARS-CoV-2 and infected cells JO: bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33173862 #FOAvip SARS-CoV-2 utilizes a number of strategies to modulate viral and host mRNA translation. Here, we used ribosome profiling in SARS-CoV-2 infected model cell lines and primary airway cells grown at the air-liquid interface to gain a deeper understanding of the translationally regulated events in response to virus replication. We find that SARS-CoV-2 mRNAs dominate the cellular mRNA pool but are not more efficiently translated than cellular mRNAs. SARS-CoV-2 utilized a highly efficient ribosomal frameshifting strategy in comparison to HIV-1, suggesting utilization of distinct structural elements. In the highly permissive cell models, although SARS-CoV-2 infection induced the transcriptional upregulation of numerous chemokines, cytokines and interferon stimulated genes, many of these mRNAs were not translated efficiently. Impact of SARS-CoV-2 on host mRNA translation was more subtle in primary cells, with marked transcriptional and translational upregulation of inflammatory and innate immune responses and downregulation of processes involved in ciliated cell function. Together, these data reveal the key role of mRNA translation in SARS-CoV-2 replication and highlight unique mechanisms for therapeutic development. Twit Text FOAVip The translational landscape of SARS-CoV-2 and infected cells ????bioRxiv http://www.kidney.de/pget.php?&tw=1&pmid=33173862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33173862 #FOAvip English Wikipedia <ref>{{Cite pmid|33173862}}</ref> The translational landscape of SARS-CoV-2 and infected cells #MMPMID33173862 Puray-Chavez M; Lee N; Tenneti K; Wang Y; Vuong HR; Liu Y; Horani A; Huang T; Gunsten SP; Case JB; Yang W; Diamond MS; Brody SL; Dougherty J; Kutluay SB bioRxiv 2021[Oct]; ä (ä): ä PMID33173862show ga SARS-CoV-2 utilizes a number of strategies to modulate viral and host mRNA translation. Here, we used ribosome profiling in SARS-CoV-2 infected model cell lines and primary airway cells grown at the air-liquid interface to gain a deeper understanding of the translationally regulated events in response to virus replication. We find that SARS-CoV-2 mRNAs dominate the cellular mRNA pool but are not more efficiently translated than cellular mRNAs. SARS-CoV-2 utilized a highly efficient ribosomal frameshifting strategy in comparison to HIV-1, suggesting utilization of distinct structural elements. In the highly permissive cell models, although SARS-CoV-2 infection induced the transcriptional upregulation of numerous chemokines, cytokines and interferon stimulated genes, many of these mRNAs were not translated efficiently. Impact of SARS-CoV-2 on host mRNA translation was more subtle in primary cells, with marked transcriptional and translational upregulation of inflammatory and innate immune responses and downregulation of processes involved in ciliated cell function. Together, these data reveal the key role of mRNA translation in SARS-CoV-2 replication and highlight unique mechanisms for therapeutic development. äThe translational landscape of SARS-CoV-2 and infected cells (epmc).pdf DeepDyve Pubget Overpricing