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10.1016/j.peptides.2020.170443 http://scihub22266oqcxt.onion/10.1016/j.peptides.2020.170443 33171280!7648656!33171280     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33171280&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Peptides 2021 ; 136 (?): 170443 Nephropedia Template TP {{tp|p=33171280|t=2021. Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease |pdf=|usr=}}{{33171280}} gab.com Text Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease JO: Peptides http://www.kidney.de/pget.php?&tw=1&pmid=33171280 #FOAvip The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that could serve as a safe, potent and robust therapy against the neurovirulent Enterovirus A71 (EV-A71). Natural peptides such as lactoferrin, melittin and synthetic peptides such as SP40, RGDS and LVLQTM have been studied against EV-A71 and have shown promising results as potent antivirals in pre-clinical studies. Peptides are considered safe, efficacious and pose fewer chances of resistance. Poor pharmacokinetic features of peptides can be overcome by the use of chemical modifications to improve in vivo delivery particularly by oral route. The use of nanotechnology can remarkably assist in the oral delivery of peptides and enhance stability in vivo. This can greatly increase patient compliance and make it more attractive as antiviral therapy. Twit Text FOAVip Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease ????Peptides http://www.kidney.de/pget.php?&tw=1&pmid=33171280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33171280 #FOAvip English Wikipedia <ref>{{Cite pmid|33171280}}</ref> Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease #MMPMID33171280 Lalani S; Gew LT; Poh CL Peptides 2021[Feb]; 136 (?): 170443 PMID33171280show ga The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that could serve as a safe, potent and robust therapy against the neurovirulent Enterovirus A71 (EV-A71). Natural peptides such as lactoferrin, melittin and synthetic peptides such as SP40, RGDS and LVLQTM have been studied against EV-A71 and have shown promising results as potent antivirals in pre-clinical studies. Peptides are considered safe, efficacious and pose fewer chances of resistance. Poor pharmacokinetic features of peptides can be overcome by the use of chemical modifications to improve in vivo delivery particularly by oral route. The use of nanotechnology can remarkably assist in the oral delivery of peptides and enhance stability in vivo. This can greatly increase patient compliance and make it more attractive as antiviral therapy. |Antiviral Agents/*therapeutic use[MESH] |Enterovirus A, Human/drug effects/*genetics[MESH] |Hand, Foot and Mouth Disease/*drug therapy/genetics/virology[MESH] |Humans[MESH]Antiviral peptides against Enterovirus A71 causing hand, foot and mout(epmc).pdf DeepDyve Pubget Overpricing