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10.1016/j.exger.2020.111147 http://scihub22266oqcxt.onion/10.1016/j.exger.2020.111147 33171276!7648491!33171276     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Gerontol 2020 ; 142 (ä): 111147 Nephropedia Template TP {{tp|p=33171276|t=2020. Age-related mitochondrial dysfunction as a key factor in COVID-19 disease |pdf=|usr=}}{{33171276}} gab.com Text Age-related mitochondrial dysfunction as a key factor in COVID-19 disease JO: Exp Gerontol http://www.kidney.de/pget.php?&tw=1&pmid=33171276 #FOAvip SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes, lung and cardiovascular diseases, all of them age-associated diseases, increase the severity and lethality of COVID-19. Mitochondrial dysfunction is one of the hallmarks of aging and COVID-19 risk factors. Dysfunctional mitochondria is associated with defective immunological response to viral infections and chronic inflammation. This review discuss how mitochondrial dysfunction is associated with defective immune response in aging and different age-related diseases, and with many of the comorbidities associated with poor prognosis in the progression of COVID-19. We suggest here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients. Preventive treatments based on therapies improving mitochondrial turnover, dynamics and activity would be essential to protect against COVID-19 severity. Twit Text FOAVip Age-related mitochondrial dysfunction as a key factor in COVID-19 disease ????Exp Gerontol http://www.kidney.de/pget.php?&tw=1&pmid=33171276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33171276 #FOAvip English Wikipedia <ref>{{Cite pmid|33171276}}</ref> Age-related mitochondrial dysfunction as a key factor in COVID-19 disease #MMPMID33171276 Moreno Fernandez-Ayala DJ; Navas P; Lopez-Lluch G Exp Gerontol 2020[Dec]; 142 (ä): 111147 PMID33171276show ga SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense cytokine storm leading finally to a multi-organ failure and death. Comorbidities such as metabolic syndrome, obesity, type 2 diabetes, lung and cardiovascular diseases, all of them age-associated diseases, increase the severity and lethality of COVID-19. Mitochondrial dysfunction is one of the hallmarks of aging and COVID-19 risk factors. Dysfunctional mitochondria is associated with defective immunological response to viral infections and chronic inflammation. This review discuss how mitochondrial dysfunction is associated with defective immune response in aging and different age-related diseases, and with many of the comorbidities associated with poor prognosis in the progression of COVID-19. We suggest here that chronic inflammation caused by mitochondrial dysfunction is responsible of the explosive release of inflammatory cytokines causing severe pneumonia, multi-organ failure and finally death in COVID-19 patients. Preventive treatments based on therapies improving mitochondrial turnover, dynamics and activity would be essential to protect against COVID-19 severity. |*SARS-CoV-2[MESH] |Aging/*immunology[MESH] |Animals[MESH] |COVID-19/*complications/immunology/mortality[MESH] |Cytokine Release Syndrome/etiology[MESH] |Humans[MESH] |Inflammation/immunology/physiopathology[MESH] |Mitochondria/*physiology[MESH]Age-related mitochondrial dysfunction as a key factor in COVID-19 dise(epmc).pdf DeepDyve Pubget Overpricing