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10.1042/BST20200744 http://scihub22266oqcxt.onion/10.1042/BST20200744 33170924!ä!33170924 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Soc+Trans 2020 ; 48 (6): 2851-2863 Nephropedia Template TP {{tp|p=33170924|t=2020. Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications |pdf=|usr=}}{{33170924}} gab.com Text Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=33170924 #FOAvip The ongoing COVID-19 pandemic has placed an overwhelming burden on the healthcare system, and caused major disruption to the world economy. COVID-19 is caused by SARS-CoV-2, a novel coronavirus that leads to a variety of symptoms in humans, including cough, fever and respiratory failure. SARS-CoV-2 infection can trigger extensive immune responses, including the production of antibodies. The detection of antibody response by serological testing provides a supplementary diagnostic tool to molecular tests. We hereby present a succinct yet comprehensive review on the antibody response to SARS-CoV-2 infection, as well as molecular mechanisms behind the strengths and limitations of serological antibody tests. The presence of antibodies can be detected in patient sera within days post symptom onset. Serological tests demonstrate superior sensitivity to molecular tests in some periods of time during disease development. Compared with the molecular tests, serological tests can be used for point-of-care testing, providing faster results at a lower cost. Commercially available serological tests show variable sensitivity and specificity, and the molecular basis of these variabilities are analysed. We discuss assays of different complexities that are used to specifically quantitate neutralising antibodies against SARS-CoV-2, which has important implications for vaccine development and herd immunity. Furthermore, we discuss examples of successful applications of serological tests to contact tracing and community-level sero-surveying, which provide invaluable information for pandemic management and assessment. Twit Text FOAVip Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=33170924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33170924 #FOAvip English Wikipedia <ref>{{Cite pmid|33170924}}</ref> Serological antibody testing in the COVID-19 pandemic: their molecular basis and applications #MMPMID33170924 Jiang JC; Zhang Y Biochem Soc Trans 2020[Dec]; 48 (6): 2851-2863 PMID33170924show ga The ongoing COVID-19 pandemic has placed an overwhelming burden on the healthcare system, and caused major disruption to the world economy. COVID-19 is caused by SARS-CoV-2, a novel coronavirus that leads to a variety of symptoms in humans, including cough, fever and respiratory failure. SARS-CoV-2 infection can trigger extensive immune responses, including the production of antibodies. The detection of antibody response by serological testing provides a supplementary diagnostic tool to molecular tests. We hereby present a succinct yet comprehensive review on the antibody response to SARS-CoV-2 infection, as well as molecular mechanisms behind the strengths and limitations of serological antibody tests. The presence of antibodies can be detected in patient sera within days post symptom onset. Serological tests demonstrate superior sensitivity to molecular tests in some periods of time during disease development. Compared with the molecular tests, serological tests can be used for point-of-care testing, providing faster results at a lower cost. Commercially available serological tests show variable sensitivity and specificity, and the molecular basis of these variabilities are analysed. We discuss assays of different complexities that are used to specifically quantitate neutralising antibodies against SARS-CoV-2, which has important implications for vaccine development and herd immunity. Furthermore, we discuss examples of successful applications of serological tests to contact tracing and community-level sero-surveying, which provide invaluable information for pandemic management and assessment. |*COVID-19 Serological Testing/methods/standards[MESH] |Antibodies, Viral/analysis/blood[MESH] |COVID-19/*diagnosis/epidemiology[MESH] |Humans[MESH] |Molecular Diagnostic Techniques/methods/standards[MESH] |Pandemics[MESH] |Reproducibility of Results[MESH] |SARS-CoV-2/chemistry/genetics/*immunology[MESH] |Sensitivity and Specificity[MESH] |Serologic Tests/methods/standards[MESH]Serological antibody testing in the COVID-19 pandemic: their molecular(epmc).pdf DeepDyve Pubget Overpricing