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10.1007/s00408-020-00408-4 http://scihub22266oqcxt.onion/10.1007/s00408-020-00408-4 33170317!7653219!33170317     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33170317&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33170317.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Lung 2020 ; 198 (6): 867-877 Nephropedia Template TP {{tp|p=33170317|t=2020. ACE2: The Major Cell Entry Receptor for SARS-CoV-2 |pdf=|usr=}}{{33170317}} gab.com Text ACE2: The Major Cell Entry Receptor for SARS-CoV-2 JO: Lung http://www.kidney.de/pget.php?&tw=1&pmid=33170317 #FOAvip Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus has infected more than 46 million people worldwide, killing over one million two hundred thousand. Understanding the mechanisms by which some individuals are more susceptible to SARS-CoV-2 infection and why a subgroup of them are prone to experience severe pneumonia, and death should lead to a better approach and more effective treatments for COVID-19. Here, we focus our attention on ACE2, a primary receptor of SARS-CoV-2. We will discuss its biology, tissue expression, and post-translational regulation that determine its potential to be employed by SARS-CoV-2 for cell entry. Particular attention will be given to how the ACE2 soluble form can have a great impact on disease progression and thus be used in a potential therapeutic strategy. Furthermore, we will discuss repercussions that SARS-CoV-2/ACE2 binding has on the renin-angiotensin system and beyond. Indeed, although mostly neglected, ACE2 can also act on [des-Arg 937]-bradykinin of the kinin-kallikrein system regulating coagulation and inflammation. Thorough comprehension of the role that ACE2 plays in different pathways will be the key to assess the impact that SARS-CoV-2/ACE2 binding has on organismal physiology and will help us to find better therapies and diagnostic tools. Twit Text FOAVip ACE2: The Major Cell Entry Receptor for SARS-CoV-2 ????Lung http://www.kidney.de/pget.php?&tw=1&pmid=33170317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33170317 #FOAvip English Wikipedia <ref>{{Cite pmid|33170317}}</ref> ACE2: The Major Cell Entry Receptor for SARS-CoV-2 #MMPMID33170317 Scialo F; Daniele A; Amato F; Pastore L; Matera MG; Cazzola M; Castaldo G; Bianco A Lung 2020[Dec]; 198 (6): 867-877 PMID33170317show ga Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus has infected more than 46 million people worldwide, killing over one million two hundred thousand. Understanding the mechanisms by which some individuals are more susceptible to SARS-CoV-2 infection and why a subgroup of them are prone to experience severe pneumonia, and death should lead to a better approach and more effective treatments for COVID-19. Here, we focus our attention on ACE2, a primary receptor of SARS-CoV-2. We will discuss its biology, tissue expression, and post-translational regulation that determine its potential to be employed by SARS-CoV-2 for cell entry. Particular attention will be given to how the ACE2 soluble form can have a great impact on disease progression and thus be used in a potential therapeutic strategy. Furthermore, we will discuss repercussions that SARS-CoV-2/ACE2 binding has on the renin-angiotensin system and beyond. Indeed, although mostly neglected, ACE2 can also act on [des-Arg 937]-bradykinin of the kinin-kallikrein system regulating coagulation and inflammation. Thorough comprehension of the role that ACE2 plays in different pathways will be the key to assess the impact that SARS-CoV-2/ACE2 binding has on organismal physiology and will help us to find better therapies and diagnostic tools. |Angiotensin-Converting Enzyme 2/*physiology[MESH] |COVID-19/diagnosis/*etiology/therapy[MESH] |Humans[MESH] |Receptors, Coronavirus/physiology[MESH] |Renin-Angiotensin System/physiology[MESH] |SARS-CoV-2/*physiology[MESH]ACE2: The Major Cell Entry Receptor for SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing