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10.1038/s41590-020-00828-7 http://scihub22266oqcxt.onion/10.1038/s41590-020-00828-7 33169014!8130642!33169014     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2021 ; 22 (1): 67-73 Nephropedia Template TP {{tp|p=33169014|t=2021. Proinflammatory IgG Fc structures in patients with severe COVID-19 |pdf=|usr=}}{{33169014}} gab.com Text Proinflammatory IgG Fc structures in patients with severe COVID-19 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33169014 #FOAvip Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcgamma receptor FcgammaRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1. Twit Text FOAVip Proinflammatory IgG Fc structures in patients with severe COVID-19 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33169014 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33169014 #FOAvip English Wikipedia <ref>{{Cite pmid|33169014}}</ref> Proinflammatory IgG Fc structures in patients with severe COVID-19 #MMPMID33169014 Chakraborty S; Gonzalez J; Edwards K; Mallajosyula V; Buzzanco AS; Sherwood R; Buffone C; Kathale N; Providenza S; Xie MM; Andrews JR; Blish CA; Singh U; Dugan H; Wilson PC; Pham TD; Boyd SD; Nadeau KC; Pinsky BA; Zhang S; Memoli MJ; Taubenberger JK; Morales T; Schapiro JM; Tan GS; Jagannathan P; Wang TT Nat Immunol 2021[Jan]; 22 (1): 67-73 PMID33169014show ga Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcgamma receptor FcgammaRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/*immunology/metabolism/virology[MESH] |Child[MESH] |Cytokines/*immunology/metabolism[MESH] |Female[MESH] |Glycosylation[MESH] |Humans[MESH] |Immunoglobulin G/*immunology/metabolism[MESH] |Interleukin-6[MESH] |Male[MESH] |Middle Aged[MESH] |Receptors, IgG/*immunology/metabolism[MESH] |SARS-CoV-2/*immunology/metabolism/physiology[MESH] |Severity of Illness Index[MESH]Proinflammatory IgG Fc structures in patients with severe COVID-19 (epmc).pdf DeepDyve Pubget Overpricing