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10.1016/j.intimp.2020.107121 http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.107121 33168413!7608005!33168413     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33168413&cmd=llinks): Failed to open stream: HTTP request failed! 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Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up |pdf=|usr=}}{{33168413}} gab.com Text Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33168413 #FOAvip BACKGROUND: Understanding the immunological responses in COVID-19 patients during their recovery period is essential to the development of a vaccine and herd immunity. METHODS: This retrospective cohort study screened 233 patients admitted to the First Hospital of Changsha, China with COVID-19 from January 17th to February 29th, 2020. After completion of SARS-CoV2-specific immunoglobulins, and T cells tests at 2-week and 3-month follow-up points after discharge, 87 were enrolled. Wilcoxon signed-rank test was performed to assess changes in the values of IgG and IgM, the number of CD3+, CD4+ and CD8+ T cells, and CD4+/CD8+ ratio during the 3-month follow-up. Linear regressions were used to evaluate the associations of immunological changes and medications during hospitalization. RESULTS: The positive rate of IgG decreased from 98.6% (40/41) to 85.4% (35/41) in men and 100% (43/43) to 76.7% (33/43) in women, whereas IgM declined from 34.1% (14/41) to 12.2% (5/41) in men and 37.2% (16/43) to 27.9% (12/43) in women during the follow-up. CD4+ T cells increased from (median (IQR), 484 (384-635)) cells/ul to 543 (414-657) cells/ul (P = 0.01). Antibiotic use was negatively associated with IgG change (mean change [95%CI], 8.08 [0.80-15.37] U, P = 0.03), and glucocorticoid use was positively related to increased CD4+ T cells (100.85 [16.56-185.15] cells/ul, P = 0.02). CONCLUSION: This study demonstrated that the positive rates and values of IgG and IgM decreased in COVID-19 patients over a 3-month follow-up, while CD4+ T cells significantly increased. Moreover, we found that antibiotic use during hospitalization was associated with IgG decrease, and glucocorticoid use was associated with increases in CD4+ T cells. Twit Text FOAVip Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33168413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33168413 #FOAvip English Wikipedia <ref>{{Cite pmid|33168413}}</ref> Associations of medications used during hospitalization and immunological changes in patients with COVID-19 during 3-month follow-up #MMPMID33168413 Liu C; Dun Y; Liu P; You B; Shu K; Luo H; Ripley-Gonzalez JW; Liu S; Liu J; Li B Int Immunopharmacol 2020[Dec]; 89 (Pt A): 107121 PMID33168413show ga BACKGROUND: Understanding the immunological responses in COVID-19 patients during their recovery period is essential to the development of a vaccine and herd immunity. METHODS: This retrospective cohort study screened 233 patients admitted to the First Hospital of Changsha, China with COVID-19 from January 17th to February 29th, 2020. After completion of SARS-CoV2-specific immunoglobulins, and T cells tests at 2-week and 3-month follow-up points after discharge, 87 were enrolled. Wilcoxon signed-rank test was performed to assess changes in the values of IgG and IgM, the number of CD3+, CD4+ and CD8+ T cells, and CD4+/CD8+ ratio during the 3-month follow-up. Linear regressions were used to evaluate the associations of immunological changes and medications during hospitalization. RESULTS: The positive rate of IgG decreased from 98.6% (40/41) to 85.4% (35/41) in men and 100% (43/43) to 76.7% (33/43) in women, whereas IgM declined from 34.1% (14/41) to 12.2% (5/41) in men and 37.2% (16/43) to 27.9% (12/43) in women during the follow-up. CD4+ T cells increased from (median (IQR), 484 (384-635)) cells/ul to 543 (414-657) cells/ul (P = 0.01). Antibiotic use was negatively associated with IgG change (mean change [95%CI], 8.08 [0.80-15.37] U, P = 0.03), and glucocorticoid use was positively related to increased CD4+ T cells (100.85 [16.56-185.15] cells/ul, P = 0.02). CONCLUSION: This study demonstrated that the positive rates and values of IgG and IgM decreased in COVID-19 patients over a 3-month follow-up, while CD4+ T cells significantly increased. Moreover, we found that antibiotic use during hospitalization was associated with IgG decrease, and glucocorticoid use was associated with increases in CD4+ T cells. |*SARS-CoV-2[MESH] |Adolescent[MESH] |Adult[MESH] |Antiviral Agents/therapeutic use[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Glucocorticoids/therapeutic use[MESH] |Hospitalization[MESH] |Humans[MESH] |Immunoglobulin G/analysis[MESH] |Immunoglobulin M/analysis[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH]Associations of medications used during hospitalization and immunologi(epmc).pdf DeepDyve Pubget Overpricing