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10.1186/s13054-020-03367-7 http://scihub22266oqcxt.onion/10.1186/s13054-020-03367-7 33168049!7652676!33168049     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Care 2020 ; 24 (1): 642 Nephropedia Template TP {{tp|p=33168049|t=2020. Point of care aspergillus testing in intensive care patients |pdf=|usr=}}{{33168049}} gab.com Text Point of care aspergillus testing in intensive care patients JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=33168049 #FOAvip BACKGROUND: Invasive pulmonary aspergillosis (IPA) is an increasingly recognized complication in intensive care unit (ICU) patients, especially those with influenza, cirrhosis, chronic obstructive pulmonary disease, and other diseases. The diagnosis can be challenging, especially in the ICU, where clinical symptoms as well as imaging are mostly nonspecific. Recently, Aspergillus lateral flow tests were developed to decrease the time to diagnosis of IPA. Several studies have shown promising results in bronchoalveolar lavage fluid (BALf) from hematology patients. We therefore evaluated a new lateral flow test for IPA in ICU patients. METHODS: Using left-over BALf from adult ICU patients in two university hospitals, we studied the performance of the Aspergillus galactomannan lateral flow assay (LFA) by IMMY (Norman, OK, USA). Patients were classified according to the 2008 EORTC-MSG definitions, the AspICU criteria, and the modified AspICU criteria, which incorporate galactomannan results. These internationally recognized consensus definitions for the diagnosis of IPA incorporate patient characteristics, microbiology and radiology. The LFA was read out visually and with a digital reader by researchers blinded to the final clinical diagnosis and IPA classification. RESULTS: We included 178 patients, of which 55 were classified as cases (6 cases of proven and 26 cases of probable IPA according to the EORTC-MSG definitions, and an additional 23 cases according to the modified AspICU criteria). Depending on the definitions used, the sensitivity of the LFA was 0.88-0.94, the specificity was 0.81, and the area under the ROC curve 0.90-0.94, indicating good overall test performance. CONCLUSIONS: In ICU patients, the LFA performed well on BALf and can be used as a rapid screening test while waiting for other microbiological results. Twit Text FOAVip Point of care aspergillus testing in intensive care patients ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=33168049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33168049 #FOAvip English Wikipedia <ref>{{Cite pmid|33168049}}</ref> Point of care aspergillus testing in intensive care patients #MMPMID33168049 Mercier T; Dunbar A; Veldhuizen V; Holtappels M; Schauwvlieghe A; Maertens J; Rijnders B; Wauters J Crit Care 2020[Nov]; 24 (1): 642 PMID33168049show ga BACKGROUND: Invasive pulmonary aspergillosis (IPA) is an increasingly recognized complication in intensive care unit (ICU) patients, especially those with influenza, cirrhosis, chronic obstructive pulmonary disease, and other diseases. The diagnosis can be challenging, especially in the ICU, where clinical symptoms as well as imaging are mostly nonspecific. Recently, Aspergillus lateral flow tests were developed to decrease the time to diagnosis of IPA. Several studies have shown promising results in bronchoalveolar lavage fluid (BALf) from hematology patients. We therefore evaluated a new lateral flow test for IPA in ICU patients. METHODS: Using left-over BALf from adult ICU patients in two university hospitals, we studied the performance of the Aspergillus galactomannan lateral flow assay (LFA) by IMMY (Norman, OK, USA). Patients were classified according to the 2008 EORTC-MSG definitions, the AspICU criteria, and the modified AspICU criteria, which incorporate galactomannan results. These internationally recognized consensus definitions for the diagnosis of IPA incorporate patient characteristics, microbiology and radiology. The LFA was read out visually and with a digital reader by researchers blinded to the final clinical diagnosis and IPA classification. RESULTS: We included 178 patients, of which 55 were classified as cases (6 cases of proven and 26 cases of probable IPA according to the EORTC-MSG definitions, and an additional 23 cases according to the modified AspICU criteria). Depending on the definitions used, the sensitivity of the LFA was 0.88-0.94, the specificity was 0.81, and the area under the ROC curve 0.90-0.94, indicating good overall test performance. CONCLUSIONS: In ICU patients, the LFA performed well on BALf and can be used as a rapid screening test while waiting for other microbiological results. |Aged[MESH] |Belgium/epidemiology[MESH] |Diagnostic Techniques and Procedures/*standards/statistics & numerical data[MESH] |Female[MESH] |Humans[MESH] |Intensive Care Units/organization & administration/statistics & numerical data[MESH] |Invasive Pulmonary Aspergillosis/*diagnosis/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Netherlands/epidemiology[MESH] |Point-of-Care Testing[MESH] |ROC Curve[MESH] |Sensitivity and Specificity[MESH]Point of care aspergillus testing in intensive care patients (epmc).pdf DeepDyve Pubget Overpricing