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10.1186/s10020-020-00231-w

http://scihub22266oqcxt.onion/10.1186/s10020-020-00231-w
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33167852!7652589!33167852
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suck abstract from ncbi

pmid33167852      Mol+Med 2020 ; 26 (1): 103
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  • SARS-CoV-2 and interferon blockade #MMPMID33167852
  • Diamond B; Volpe BT; VanPatten S; Al Abed Y
  • Mol Med 2020[Nov]; 26 (1): 103 PMID33167852show ga
  • The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
  • |*Immunity, Innate[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |Bradykinin/metabolism[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Humans[MESH]
  • |Kallikreins/metabolism[MESH]
  • |Models, Immunological[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology[MESH]
  • |Renin-Angiotensin System[MESH]


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