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10.1038/s41586-020-2943-z http://scihub22266oqcxt.onion/10.1038/s41586-020-2943-z 33166988!7855185!33166988     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2021 ; 589 (7843): 603-607 Nephropedia Template TP {{tp|p=33166988|t=2021. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice |pdf=|usr=}}{{33166988}} gab.com Text COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=33166988 #FOAvip The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial morbidity and mortality. Although much has been learned in the first few months of the pandemic, many features of COVID-19 pathogenesis remain to be determined. For example, anosmia is a common presentation, and many patients with anosmia show no or only minor respiratory symptoms(1). Studies in animals infected experimentally with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19, provide opportunities to study aspects of the disease that are not easily investigated in human patients. Although the severity of COVID-19 ranges from asymptomatic to lethal(2), most experimental infections provide insights into mild disease(3). Here, using K18-hACE2 transgenic mice that were originally developed for SARS studies(4), we show that infection with SARS-CoV-2 causes severe disease in the lung and, in some mice, the brain. Evidence of thrombosis and vasculitis was detected in mice with severe pneumonia. Furthermore, we show that infusion of convalescent plasma from a recovered patient with COVID-19 protected against lethal disease. Mice developed anosmia at early time points after infection. Notably, although pre-treatment with convalescent plasma prevented most signs of clinical disease, it did not prevent anosmia. Thus, K18-hACE2 mice provide a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions. Twit Text FOAVip COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=33166988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33166988 #FOAvip English Wikipedia <ref>{{Cite pmid|33166988}}</ref> COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice #MMPMID33166988 Zheng J; Wong LR; Li K; Verma AK; Ortiz ME; Wohlford-Lenane C; Leidinger MR; Knudson CM; Meyerholz DK; McCray PB Jr; Perlman S Nature 2021[Jan]; 589 (7843): 603-607 PMID33166988show ga The ongoing coronavirus disease 2019 (COVID-19) pandemic is associated with substantial morbidity and mortality. Although much has been learned in the first few months of the pandemic, many features of COVID-19 pathogenesis remain to be determined. For example, anosmia is a common presentation, and many patients with anosmia show no or only minor respiratory symptoms(1). Studies in animals infected experimentally with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19, provide opportunities to study aspects of the disease that are not easily investigated in human patients. Although the severity of COVID-19 ranges from asymptomatic to lethal(2), most experimental infections provide insights into mild disease(3). Here, using K18-hACE2 transgenic mice that were originally developed for SARS studies(4), we show that infection with SARS-CoV-2 causes severe disease in the lung and, in some mice, the brain. Evidence of thrombosis and vasculitis was detected in mice with severe pneumonia. Furthermore, we show that infusion of convalescent plasma from a recovered patient with COVID-19 protected against lethal disease. Mice developed anosmia at early time points after infection. Notably, although pre-treatment with convalescent plasma prevented most signs of clinical disease, it did not prevent anosmia. Thus, K18-hACE2 mice provide a useful model for studying the pathological basis of both mild and lethal COVID-19 and for assessing therapeutic interventions. |*Disease Models, Animal[MESH] |Animals[MESH] |Anosmia/physiopathology/therapy/*virology[MESH] |Brain/immunology/pathology/virology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/immunology/*physiopathology/*therapy/virology[MESH] |Epithelium/immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Inflammation/pathology/therapy/virology[MESH] |Lung Diseases/pathology/therapy/virology[MESH] |Male[MESH] |Mice[MESH] |Paranasal Sinuses/immunology/virology[MESH] |SARS-CoV-2/growth & development/immunology/*pathogenicity[MESH]COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mi(epmc).pdf DeepDyve Pubget Overpricing