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10.1016/j.chroma.2020.461661

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suck abstract from ncbi


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pmid33166894      J+Chromatogr+A 2020 ; 1634 (ä): 461661
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  • A preparative chiral separation of hydroxychloroquine using supercritical fluid chromatography #MMPMID33166894
  • Wilson LJ; Mi C; Kraml CM
  • J Chromatogr A 2020[Dec]; 1634 (ä): 461661 PMID33166894show ga
  • A robust supercritical chromatography (SFC) method using an Enantiocel C2-5 column was developed for the multigram separation of the enantiomers of hydroxychloroquine (HCQ), affirming its use as a scalable technology and ability to provide quantities of each enantiomer for clinical evaluation. The enantiomers of HCQ were collected on a gram scale with greater than 99% enantiomeric excess. The S and R enantiomer elution order was confirmed using optical rotation determinations with comparison to previously determined assignments.
  • |*Chemistry Techniques, Analytical[MESH]
  • |*Chromatography, Supercritical Fluid[MESH]
  • |Hydroxychloroquine/*isolation & purification[MESH]


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