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10.1016/j.virusres.2020.198222 http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198222 33166565!7645280!33166565     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virus+Res 2021 ; 291 (ä): 198222 Nephropedia Template TP {{tp|p=33166565|t=2021. Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome |pdf=|usr=}}{{33166565}} gab.com Text Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=33166565 #FOAvip The envelope glycoprotein (E) is the smallest structural component of SARS-CoVs; plays an essential role in the viral replication starting from envelope formation to assembly. The in silico analysis of 2086 whole genome sequences from India performed in this study provides the first observation on the extensive deletion of amino acid residues in the C-terminal region of the envelope glycoprotein in 34 Indian SARS-CoV-2 genomes. These amino acid deletions map to the homopentameric interface and PDZ binding motif (PBM) present in the C-terminal region of E protein as well as immediately after the reverse primer binding region as per Charite protocol in 26 of these genomes, hence, their detection through RT-qPCR may not be hampered and therefore E gene-based RT-qPCR would still detect these isolates. Eight genomes from the State of Odisha had deletion even in the primer binding site. It is possible that the deletions in the C-terminal region of E protein of these genomes are a result of adapting to a newer geographical area and host. The information on the clinical status was available only for 9 out of 34 cases and these were asymptomatic. However, further studies are indispensable to understand the functional consequences of amino acid deletion in the C terminal region of SARS-CoV-2 envelope protein in the viral pathogenesis and host adaptation. Twit Text FOAVip Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=33166565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33166565 #FOAvip English Wikipedia <ref>{{Cite pmid|33166565}}</ref> Deletion in the C-terminal region of the envelope glycoprotein in some of the Indian SARS-CoV-2 genome #MMPMID33166565 Kumar BK; Rohit A; Prithvisagar KS; Rai P; Karunasagar I; Karunasagar I Virus Res 2021[Jan]; 291 (ä): 198222 PMID33166565show ga The envelope glycoprotein (E) is the smallest structural component of SARS-CoVs; plays an essential role in the viral replication starting from envelope formation to assembly. The in silico analysis of 2086 whole genome sequences from India performed in this study provides the first observation on the extensive deletion of amino acid residues in the C-terminal region of the envelope glycoprotein in 34 Indian SARS-CoV-2 genomes. These amino acid deletions map to the homopentameric interface and PDZ binding motif (PBM) present in the C-terminal region of E protein as well as immediately after the reverse primer binding region as per Charite protocol in 26 of these genomes, hence, their detection through RT-qPCR may not be hampered and therefore E gene-based RT-qPCR would still detect these isolates. Eight genomes from the State of Odisha had deletion even in the primer binding site. It is possible that the deletions in the C-terminal region of E protein of these genomes are a result of adapting to a newer geographical area and host. The information on the clinical status was available only for 9 out of 34 cases and these were asymptomatic. However, further studies are indispensable to understand the functional consequences of amino acid deletion in the C terminal region of SARS-CoV-2 envelope protein in the viral pathogenesis and host adaptation. |Adult[MESH] |Amino Acid Sequence[MESH] |Computer Simulation[MESH] |Coronavirus Envelope Proteins/*genetics/immunology[MESH] |Epitopes, B-Lymphocyte[MESH] |Female[MESH] |Gene Deletion[MESH] |Genome, Viral[MESH] |Humans[MESH] |India[MESH] |Male[MESH] |Middle Aged[MESH] |Real-Time Polymerase Chain Reaction[MESH]Deletion in the C-terminal region of the envelope glycoprotein in some(epmc).pdf DeepDyve Pubget Overpricing