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10.1097/ACI.0000000000000700 http://scihub22266oqcxt.onion/10.1097/ACI.0000000000000700 33164997!ä!33164997 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33164997&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Allergy+Clin+Immunol 2021 ; 21 (1): 8-15 Nephropedia Template TP {{tp|p=33164997|t=2021. Inflammatory endotypes of CRSwNP and responses to COVID-19 |pdf=|usr=}}{{33164997}} gab.com Text Inflammatory endotypes of CRSwNP and responses to COVID-19 JO: Curr Opin Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33164997 #FOAvip PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection. RECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells. SUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear. Twit Text FOAVip Inflammatory endotypes of CRSwNP and responses to COVID-19 ????Curr Opin Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33164997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33164997 #FOAvip English Wikipedia <ref>{{Cite pmid|33164997}}</ref> Inflammatory endotypes of CRSwNP and responses to COVID-19 #MMPMID33164997 Wang M; Wang C; Zhang L Curr Opin Allergy Clin Immunol 2021[Feb]; 21 (1): 8-15 PMID33164997show ga PURPOSE OF REVIEW: Coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly become a great public health hazard globally. Nasal epithelial cells are an important site for SARS-CoV-2 infection and replication. The purpose of this review is to summarize recent findings on the endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) and the potential impact of SARS-CoV-2 infection. RECENT FINDINGS: Endotypes of CRSwNP are characterized by type 1, type 2 and type 3 inflammation according to patterns of inflammatory cells and the cytokines expressed in nasal tissue. Nasal epithelial cells show the highest expression of angiotensin-converting enzyme 2 (ACE2), the receptor for attachment and entry of SARS-CoV-2 into host cells, among all investigated cells in the respiratory tree. SARS-CoV-2 infection likely leads to increased activation of T-helper-1 (Th1) cell responses. Recent studies further suggest that ACE2 may be upregulated by type 1 and downregulated by type 2 inflammatory cytokines in nasal epithelial cells. SUMMARY: Expression of ACE2 in nasal epithelial cells is influenced by inflammatory endotypes of CRSwNP. Type 1 inflammation in nasal tissue may increase the risk of SARS-CoV-2 infection by upregulating ACE2 expression. However, clinical association between CRSwNP and COVID-19 is still unclear. |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/*epidemiology/immunology/virology[MESH] |Comorbidity[MESH] |Goblet Cells/immunology[MESH] |Humans[MESH] |Inflammation/immunology[MESH] |Nasal Polyps/*epidemiology/immunology[MESH] |Rhinitis/*epidemiology/immunology[MESH] |Risk Factors[MESH] |SARS-CoV-2/*physiology[MESH] |Sinusitis/*epidemiology/immunology[MESH]Inflammatory endotypes of CRSwNP and responses to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing