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10.7554/eLife.62522 http://scihub22266oqcxt.onion/10.7554/eLife.62522 33164753!7688309!33164753     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=33164753|t=2020. Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes |pdf=|usr=}}{{33164753}} gab.com Text Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33164753 #FOAvip Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We mapped candidate cis-regulatory elements (cCREs) and linked them to putative target genes. We identified distal cCREs with age-increased activity linked to SARS-CoV-2 host entry gene TMPRSS2 in alveolar type 2 cells, which had immune regulatory signatures and harbored variants associated with respiratory traits. At the 3p21.31 COVID-19 risk locus, a candidate variant overlapped a distal cCRE linked to SLC6A20, a gene expressed in alveolar cells and with known functional association with the SARS-CoV-2 receptor ACE2. Our findings provide insight into regulatory logic underlying genes implicated in COVID-19 in individual lung cell types across age. More broadly, these datasets will facilitate interpretation of risk loci for lung diseases. Twit Text FOAVip Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33164753 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33164753 #FOAvip English Wikipedia <ref>{{Cite pmid|33164753}}</ref> Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes #MMPMID33164753 Wang A; Chiou J; Poirion OB; Buchanan J; Valdez MJ; Verheyden JM; Hou X; Kudtarkar P; Narendra S; Newsome JM; Guo M; Faddah DA; Zhang K; Young RE; Barr J; Sajti E; Misra R; Huyck H; Rogers L; Poole C; Whitsett JA; Pryhuber G; Xu Y; Gaulton KJ; Preissl S; Sun X Elife 2020[Nov]; 9 (ä): ä PMID33164753show ga Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We mapped candidate cis-regulatory elements (cCREs) and linked them to putative target genes. We identified distal cCREs with age-increased activity linked to SARS-CoV-2 host entry gene TMPRSS2 in alveolar type 2 cells, which had immune regulatory signatures and harbored variants associated with respiratory traits. At the 3p21.31 COVID-19 risk locus, a candidate variant overlapped a distal cCRE linked to SLC6A20, a gene expressed in alveolar cells and with known functional association with the SARS-CoV-2 receptor ACE2. Our findings provide insight into regulatory logic underlying genes implicated in COVID-19 in individual lung cell types across age. More broadly, these datasets will facilitate interpretation of risk loci for lung diseases. |Adult[MESH] |Age Factors[MESH] |Alveolar Epithelial Cells/classification/metabolism/virology[MESH] |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |COVID-19/*genetics/metabolism/*virology[MESH] |Child, Preschool[MESH] |Chromosome Mapping[MESH] |Gene Expression Profiling[MESH] |Genetic Variation[MESH] |Host Microbial Interactions/*genetics/physiology[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Lung/*metabolism/*virology[MESH] |Membrane Transport Proteins/genetics/metabolism[MESH] |Pandemics[MESH] |Receptors, Virus/genetics/metabolism[MESH] |SARS-CoV-2/genetics/pathogenicity[MESH] |Single-Cell Analysis[MESH]Single-cell multiomic profiling of human lungs reveals cell-type-speci(epmc).pdf DeepDyve Pubget Overpricing