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10.7554/eLife.61390 http://scihub22266oqcxt.onion/10.7554/eLife.61390 33164751!7652413!33164751     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=33164751|t=2020. ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities |pdf=|usr=}}{{33164751}} gab.com Text ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33164751 #FOAvip Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smoking status. Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis. Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SARS-CoV-2 entry receptor. Here, we provide a critical summary of the current knowledge highlighting the limitations and remaining gaps that need to be addressed to fully characterize ACE2 function in SARS-CoV-2 infection and associated pathogenesis. We also discuss ACE2 expression and potential role in the context of comorbidities associated with poor COVID-19 outcomes. Finally, we discuss the potential co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78. Twit Text FOAVip ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33164751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33164751 #FOAvip English Wikipedia <ref>{{Cite pmid|33164751}}</ref> ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities #MMPMID33164751 Zamorano Cuervo N; Grandvaux N Elife 2020[Nov]; 9 (ä): ä PMID33164751show ga Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smoking status. Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis. Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SARS-CoV-2 entry receptor. Here, we provide a critical summary of the current knowledge highlighting the limitations and remaining gaps that need to be addressed to fully characterize ACE2 function in SARS-CoV-2 infection and associated pathogenesis. We also discuss ACE2 expression and potential role in the context of comorbidities associated with poor COVID-19 outcomes. Finally, we discuss the potential co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78. |*Virus Attachment[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Basigin/physiology[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/epidemiology/*virology[MESH] |Endoplasmic Reticulum Chaperone BiP[MESH] |Gene Expression Regulation, Enzymologic[MESH] |Heparitin Sulfate/physiology[MESH] |Humans[MESH] |Hypertension/epidemiology/physiopathology[MESH] |Neuropilin-1/physiology[MESH] |Oligopeptides/physiology[MESH] |Organ Specificity[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*physiology[MESH] |Pneumonia, Viral/epidemiology/*virology[MESH] |Protein Binding[MESH] |RNA, Messenger/biosynthesis/genetics[MESH] |Receptors, Virus[MESH] |Renin-Angiotensin System/physiology[MESH] |Respiratory System/enzymology[MESH] |SARS-CoV-2[MESH] |Sialic Acids/physiology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/physiology[MESH]ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implicatio(epmc).pdf DeepDyve Pubget Overpricing