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10.4149/BLL_2020_134

http://scihub22266oqcxt.onion/10.4149/BLL_2020_134
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33164544!ä!33164544

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suck abstract from ncbi


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pmid33164544      Bratisl+Lek+Listy 2020 ; 121 (11): 817-821
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  • Ventricular repolarization indexes in patients treated with hydroxychloroquine - azithromycin combination for COVID-19 #MMPMID33164544
  • Gunay S; Caliskan S; Sigirli D; Sahin E
  • Bratisl Lek Listy 2020[]; 121 (11): 817-821 PMID33164544show ga
  • BACKGROUND: Combination of hydroxychloroquine and azithromycin for the treatment of coronavirus disease 2019 (COVID-19) carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias. OBJECTIVE: To characterize the ventricular repolarization indexes which are associated with malignant ventricular arrhythmias in patients treated with hydroxychloroquine and concomitant azithromycin for COVID-19. METHOD: A total of 81 patients who had hydroxychloroquine and azithromycin combination therapy because of possible or reverse-transcription polymertase chain reaction (RT-PCR) confirmed diagnosis of COVID-19 were included in the study. Baseline and control electrocardiograms (before and after treatment) were analyzed retrospectively. Tp-e interval, Tp-e/QT and Tp-e/QTc ratios, which are ventricular repolarization indexes, were calculated. RESULTS: While there was no significant increase in QTc interval in patients receiving combination therapy, there was a significant increase in ventricular repolarization indexes. CONCLUSION: The increase in ventricular replarization indexes is associated with the risk of arrhythmia. In patients using QTc prolonging medication for COVID-19 treatment, QTc monitoring alone may not be sufficient to follow-up for arrhythmia. Even if there is no prolongation in QTc, an increase in ventricular repolarization indexes may be seen (Tab. 5, Ref. 37).
  • |Azithromycin/*adverse effects[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Electrocardiography[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*adverse effects[MESH]
  • |Long QT Syndrome/*chemically induced[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Retrospective Studies[MESH]


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