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10.1016/j.xcrm.2020.100144 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100144 33163981!7598305!33163981     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (8): 100144 Nephropedia Template TP {{tp|p=33163981|t=2020. Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients |pdf=|usr=}}{{33163981}} gab.com Text Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33163981 #FOAvip In this single-center, retrospective cohort analysis of hospitalized coronavirus disease 2019 (COVID-19) patients, we investigate whether inflammatory biomarker levels predict respiratory decline in patients who initially present with stable disease. Examination of C-reactive protein (CRP) trends reveals that a rapid rise in CRP levels precedes respiratory deterioration and intubation, although CRP levels plateau in patients who remain stable. Increasing CRP during the first 48 h of hospitalization is a better predictor (with higher sensitivity) of respiratory decline than initial CRP levels or ROX indices (a physiological score of respiratory function). CRP, the proinflammatory cytokine interleukin-6 (IL-6), and physiological measures of hypoxemic respiratory failure are correlated, which suggests a mechanistic link. Our work shows that rising CRP predicts subsequent respiratory deterioration in COVID-19 and may suggest mechanistic insight and a potential role for targeted immunomodulation in a subset of patients early during hospitalization. Twit Text FOAVip Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33163981 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33163981 #FOAvip English Wikipedia <ref>{{Cite pmid|33163981}}</ref> Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients #MMPMID33163981 Mueller AA; Tamura T; Crowley CP; DeGrado JR; Haider H; Jezmir JL; Keras G; Penn EH; Massaro AF; Kim EY Cell Rep Med 2020[Nov]; 1 (8): 100144 PMID33163981show ga In this single-center, retrospective cohort analysis of hospitalized coronavirus disease 2019 (COVID-19) patients, we investigate whether inflammatory biomarker levels predict respiratory decline in patients who initially present with stable disease. Examination of C-reactive protein (CRP) trends reveals that a rapid rise in CRP levels precedes respiratory deterioration and intubation, although CRP levels plateau in patients who remain stable. Increasing CRP during the first 48 h of hospitalization is a better predictor (with higher sensitivity) of respiratory decline than initial CRP levels or ROX indices (a physiological score of respiratory function). CRP, the proinflammatory cytokine interleukin-6 (IL-6), and physiological measures of hypoxemic respiratory failure are correlated, which suggests a mechanistic link. Our work shows that rising CRP predicts subsequent respiratory deterioration in COVID-19 and may suggest mechanistic insight and a potential role for targeted immunomodulation in a subset of patients early during hospitalization. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/analysis[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19/*blood/*physiopathology[MESH] |Humans[MESH] |Inflammation[MESH] |Intensive Care Units[MESH] |Interleukin-6/analysis[MESH] |Middle Aged[MESH] |Prognosis[MESH] |Respiratory Insufficiency/blood/physiopathology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing