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10.1016/j.xcrm.2020.100142 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100142 33163980!7598530!33163980     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (8): 100142 Nephropedia Template TP {{tp|p=33163980|t=2020. Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells |pdf=|usr=}}{{33163980}} gab.com Text Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33163980 #FOAvip The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV) pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 spike), a bona fide system mimicking SARS-CoV-2 infection. Infection activates acid sphingomyelinase and triggers a release of ceramide on the cell surface. Neutralization or consumption of surface ceramide reduces infection with pp-VSV-SARS-CoV-2 spike. Treating volunteers with a low dose of amitriptyline prevents infection of freshly isolated nasal epithelial cells with pp-VSV-SARS-CoV-2 spike. The data justify clinical studies investigating whether amitriptyline, a safe drug used clinically for almost 60 years, or other antidepressants that functionally block acid sphingomyelinase prevent SARS-CoV-2 infection. Twit Text FOAVip Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33163980 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33163980 #FOAvip English Wikipedia <ref>{{Cite pmid|33163980}}</ref> Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells #MMPMID33163980 Carpinteiro A; Edwards MJ; Hoffmann M; Kochs G; Gripp B; Weigang S; Adams C; Carpinteiro E; Gulbins A; Keitsch S; Sehl C; Soddemann M; Wilker B; Kamler M; Bertsch T; Lang KS; Patel S; Wilson GC; Walter S; Hengel H; Pohlmann S; Lang PA; Kornhuber J; Becker KA; Ahmad SA; Fassbender K; Gulbins E Cell Rep Med 2020[Nov]; 1 (8): 100142 PMID33163980show ga The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV) pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 spike), a bona fide system mimicking SARS-CoV-2 infection. Infection activates acid sphingomyelinase and triggers a release of ceramide on the cell surface. Neutralization or consumption of surface ceramide reduces infection with pp-VSV-SARS-CoV-2 spike. Treating volunteers with a low dose of amitriptyline prevents infection of freshly isolated nasal epithelial cells with pp-VSV-SARS-CoV-2 spike. The data justify clinical studies investigating whether amitriptyline, a safe drug used clinically for almost 60 years, or other antidepressants that functionally block acid sphingomyelinase prevent SARS-CoV-2 infection. |Amitriptyline/pharmacology[MESH] |Animals[MESH] |Antidepressive Agents/pharmacology[MESH] |Ceramides/antagonists & inhibitors/metabolism[MESH] |Chlorocebus aethiops[MESH] |Epithelial Cells/*drug effects/metabolism/virology[MESH] |Humans[MESH] |Nasal Mucosa/drug effects/metabolism/virology[MESH] |Neutral Ceramidase/pharmacology[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Sphingomyelin Phosphodiesterase/*antagonists & inhibitors/metabolism[MESH] |Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH] |Vero Cells[MESH]Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of(epmc).pdf DeepDyve Pubget Overpricing